Sodium Isethionate is the sodium salt of Isetionic acid.

Used in medicine, cosmetics.

Sodium Isethionate studies

Molecular Formula: C₂H₅NaO₄S

Linear Formula: HOCH₂CH₂SO₃Na

Molecular Weight: 148.108 g/mol

UNII: 3R36J71C17

CAS: 1562-00-1  52117-27-8  78858-24-9

EC Number: 216-343-6

PubChem Substance ID 24853163

MDL number MFCD00007534

Beilstein Registry Number 3633992

Synonyms:

• Isethionic acid sodium salt
• Sodium 2-hydroxyethanesulfonate
• 2-Hydroxyethanesulfonic acid sodium salt
• Sodium hydroxyethylsulfonate
• Ethanesulfonic acid, 2-hydroxy-, monosodium salt
• Sodium beta-hydroxyethanesulfonate
• Sodium 1-hydroxy-2-ethanesulfonate
• Sodium 2-hydroxy-1-ethanesulfonate
• Sodium 2-hydroxyethyl sulfonate
• Ethanesulfonic acid, 2-hydroxy-, sodium salt
• 2-Hydroxyethanesulfonic acid, sodium salt
• Sodium 2-hydroxyethylsulfonate
• Sodium 2-hydroxyethanesulphonate
• Hydroxyethylsulfonic Acid Sodium Salt
• Sodiumisethionate
• isethionic acid sodium
• Isethionic acid, sodium salt
• Istethionic Acid Sodium Salt
• Sodium 2-Hydroxy-Ethanesulfonate

Sodium Isethionate is used as a placebo in medicine in the prophylaxis of Pneumocystis carinii pneumonia and is administered by aerosol (1).

Also used in research on insulin secretions in aging (2) in experiments on rats (3).

Other studies

Amended Safety Assessment of Isethionate Salts as Used in Cosmetics.  Burnett CL, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.  Int J Toxicol. 2017 May/Jun;36(1_suppl):5S-16S. doi: 10.1177/1091581816685552.

Identification of isethionic acid and other small molecule metabolites of Fragilariopsis cylindrus with nuclear magnetic resonance.  Boroujerdi AF, Lee PA, DiTullio GR, Janech MG, Vied SB, Bearden DW.  Anal Bioanal Chem. 2012 Aug;404(3):777-84. doi: 10.1007/s00216-012-6169-2. Epub 2012 Jul 8.

References_______________________________________________

(1) A controlled study of inhaled pentamidine for primary prevention of Pneumocystis carinii pneumonia.
Hirschel B, Lazzarin A, Chopard P, Opravil M, Furrer HJ, Rüttimann S, Vernazza P, Chave JP, Ancarani F, Gabriel V, et al.
N Engl J Med. 1991 Apr

(2) Insulin secretion in aging: studies with sequential gating of secretion vesicle margination and lysis.
Goodman M, Leitner JW, Sussman KE, Draznin B.
Endocrinology. 1986 Aug

(3) Feedback inhibition of insulin on insulin secretion in isolated pancreatic islets.
Draznin B, Goodman M, Leitner JW, Sussman KE.
Endocrinology. 1986 Mar