Compendium of the most significant studies with reference to properties, intake, effects.

In Vitro and In Vivo Evaluation of the Anticancer and Anti-inflammatory Activities of 2-Himachelen-7-ol isolated from Cedrus Libani. Elias A, Shebaby WN, Nehme B, Faour W, Bassil BS, Hakim JE, Iskandar R, Dib-Jalbout N, Mroueh M, Daher C, Taleb RI. Sci Rep. 2019 Sep 6;9(1):12855. doi: 10.1038/s41598-019-49374-9.

Cedrus deodara: In vitro antileishmanial efficacy & immumomodulatory activity.
Narayan S, Thakur CP, Bahadur S, Thakur M, Pandey SN, Thakur AK, Mitra DK, Mukherjee PK.
Indian J Med Res. 2017 Dec;146(6):780-787. doi: 10.4103/ijmr.IJMR_959_16

The Occurrence of Flavonoids and Related Compounds in Cedrus brevifolia A. Henry ex Elwes & A. Henry Needles. Inhibitory Potencies on Lipoxygenase, Linoleic Acid Lipid Peroxidation and Antioxidant Activity.
Douros A, Hadjipavlou-Litina D, Nikolaou K, Skaltsa H.
Plants (Basel). 2017 Dec 27;7(1). pii: E1. doi: 10.3390/plants7010001

Odor-active constituents of Cedrus atlantica wood essential oil.
Uehara A, Tommis B, Belhassen E, Satrani B, Ghanmi M, Baldovini N.
Phytochemistry. 2017 Dec;144:208-215. doi: 10.1016/j.phytochem.2017.09.017.

Antibacterial Activity of Shikimic Acid from Pine Needles of Cedrus deodara against Staphylococcus aureus through Damage to Cell Membrane.
Bai J, Wu Y, Liu X, Zhong K, Huang Y, Gao H.
Int J Mol Sci. 2015 Nov 13;16(11):27145-55. doi: 10.3390/ijms161126015

Inhalation of Cedrus atlantica essential oil alleviates pain behavior through activation of descending pain modulation pathways in a mouse model of postoperative pain.
Martins DF, Emer AA, Batisti AP, Donatello N, Carlesso MG, Mazzardo-Martins L, Venzke D, Micke GA, Pizzolatti MG, Piovezan AP, dos Santos AR.
J Ethnopharmacol. 2015 Dec 4;175:30-8. doi: 10.1016/j.jep.2015.08.048.

Membrane stabilizing activity — a possible mechanism of action for the anti-inflammatory activity of Cedrus deodara wood oil  U.A.Shinde.S.PhadkeA.M.NairA.A.MungantiwarV.J.DikshitM.N.Saraf https://doi.org/10.1016/S0367-326X(99)00030-1

Cedar is the fruit of conifers of the genus Cedrus belonging to the family of the Pinaceae, native to the Mediterranean, Lebanon, Syria, Turkey.

Popular plants of the genus Cedrus: Cedrus Libani, Cedrus deodara, Cedrus brevifolia. Cedrus atlantica

The plant and its fruits have been used for centuries in traditional medicine against various diseases.

Its composition includes steroids, procyanidins and terpenoids.

In particular, in the seeds are present chloroform, alpha-pinene and beta-pinene in a rather abundant measure which, probably, are involved in the antiproliferative activity against leukemic cells K562 (1).

A new phenolic compound, 3-p-trans-coumaroyl-2-hydroxyquinic acid, isolated from Cedrus deodara, has proven effective against certain bacteria including Staphylococcus aureus. The discovery is interesting because of the great demand of the food industry for natural antibacterial agents (2).

Another interesting active compound, also obtained from Cedrus deodara pine needles, 2R,3R-dihydromyricetin, has shown a strong anti-oxidative capacity and can be used to prevent browning of foods (3).

The fruits contain vitamin C and traces of minerals, but there is no evidence in the scientific literature of the benefits celebrated by ethnic medicine.

An essential oil with antimicrobial and antifungal properties is obtained from the wood.

Cedar studies

References_____________________________________

(1) Antiproliferative and Erythroid Differentiation Activities of Cedrus libani Seed  Extracts against K562 Human Chronic Myelogenus Leukemia Cells Antoine M. Saab, Ilaria Lampronti, Alessandro Grandini, Monica Borgatti, Alessia Finotti,
Gianni Sacchetti,  Roberto Gambari, Alessandra Guerrini  International Journal of Pharmaceutical & Biological Archives 2011; 2(6):1744-1748

(2) Antibacterial Activity and Membrane-Disruptive Mechanism of 3-p-trans-Coumaroyl-2-hydroxyquinic Acid, a Novel Phenolic Compound from Pine Needles of Cedrus deodara, against Staphylococcus aureus.  Wu Y, Bai J, Zhong K, Huang Y, Qi H, Jiang Y, Gao H.  Molecules. 2016 Aug 18;21(8). pii: E1084. doi: 10.3390/molecules21081084.

(3) A potent antibrowning agent from pine needles of Cedrus deodara: 2R,3R-dihydromyricetin.  Liang X, Wu YP, Qiu JH, Zhong K, Gao H.  J Food Sci. 2014 Sep;79(9):C1643-8. doi: 10.1111/1750-3841.12583.