Antihyperglycemic and antihyperlipidemic activities of methanol:water (4:1) fraction isolated from aqueous extract of Syzygium alternifolium seeds in streptozotocin induced diabetic rats.  Kasetti RB, Rajasekhar MD, Kondeti VK, Fatima SS, Kumar EG, Swapna S, Ramesh B, Rao CA.  Food Chem Toxicol. 2010 Apr;48(4):1078-84. doi: 10.1016/j.fct.2010.01.029

Antibacterial and antibiofilm activity of acetone leaf extracts of nine under-investigated south African Eugenia and Syzygium (Myrtaceae) species and their selectivity indices.
Famuyide IM, Aro AO, Fasina FO, Eloff JN, McGaw LJ.
BMC Complement Altern Med. 2019 Jun 20;19(1):141. doi: 10.1186/s12906-019-2547-z.

Larvicidal Activity of Essential Oil of Syzygium aromaticum (Clove) in Comparison with Its Major Constituent, Eugenol, against Anopheles stephensi.
Osanloo M, Sedaghat MM, Esmaeili F, Amani A.
J Arthropod Borne Dis. 2018 Dec 25;12(4):361-369.

Antimicrobial potential of toothpaste formulated from extracts of Syzygium aromaticum, Dennettia tripetala and Jatropha curcas latex against some oral pathogenic microorganisms.
Oluwasina OO, Ezenwosu IV, Ogidi CO, Oyetayo VO.
AMB Express. 2019 Feb 4;9(1):20. doi: 10.1186/s13568-019-0744-2.

Syzygium aromaticum aqueous extract inhibits human neutrophils myeloperoxidase and protects mice from LPS-induced lung inflammation.
Chniguir A, Zioud F, Marzaioli V, El-Benna J, Bachoual R.
Pharm Biol. 2019 Dec;57(1):56-64. doi: 10.1080/13880209.2018.1557697.

Anticancer Potential of Syzygium Species: a Review.
Chua LK, Lim CL, Ling APK, Chye SM, Koh RY.
Plant Foods Hum Nutr. 2019 Mar;74(1):18-27. doi: 10.1007/s11130-018-0704-z.

Antimicrobial and antioxidant activity of unencapsulated and encapsulated clove (Syzygium aromaticum, L.) essential oil.
Radünz M, da Trindade MLM, Camargo TM, Radünz AL, Borges CD, Gandra EA, Helbig E.
Food Chem. 2019 Mar 15;276:180-186. doi: 10.1016/j.foodchem.2018.09.173.

Safety

Essential Oils as a Feed Additives: Pharmacokinetics and Potential Toxicity in Monogastric Animals.  Horky P, Skalickova S, Smerkova K, Skladanka J.  Animals (Basel). 2019 Jun 13;9(6). pii: E352. doi: 10.3390/ani9060352. Review.

The Cloves ( Syzygium aromaticum ) is the aromatic flower of a green tree that can reach 15 meters in height and is found mainly in Madagascar, Ceylon and Indonesia.

They are used in

• Food as food flavorers
• Medicine as anti-inflammatory , anesthetic

In traditional medicine, they have traditionally been used to treat various disorders such as diabetes, diarrhea, reproductive problems and respiratory disorders (1).

Recent studies have shown its antibacterial efficacy (2).

The essential oil of cloves showed genoprotective effects (3).

Other plants of the Syzygium species that have shown healing properties:

• Syzygium cumini L.
• Syzygium polyanthum (Wight.) 
• Syzygium malaccense 
• Syzygium brazzavillense
• Syzygium formosum (Wall.)
• Syzygium polyanthum 
• Syzygium paniculatum Gaertn.
• Syzygium guineense 

Cloves studies

References_____________________________________

(1) Antihyperglycemic and antihyperlipidemic activities of methanol:water (4:1) fraction isolated from aqueous extract of Syzygium alternifolium seeds in streptozotocin induced diabetic rats.  Kasetti RB, Rajasekhar MD, Kondeti VK, Fatima SS, Kumar EG, Swapna S, Ramesh B, Rao CA.  Food Chem Toxicol. 2010 Apr;48(4):1078-84. doi: 10.1016/j.fct.2010.01.029

(2) Antibacterial and antibiofilm activity of acetone leaf extracts of nine under-investigated south African Eugenia and Syzygium (Myrtaceae) species and their selectivity indices.  Famuyide IM, Aro AO, Fasina FO, Eloff JN, McGaw LJ.  BMC Complement Altern Med. 2019 Jun 20;19(1):141. doi: 10.1186/s12906-019-2547-z.

(3) Essential Oils as a Feed Additives: Pharmacokinetics and Potential Toxicity in Monogastric Animals.  Horky P, Skalickova S, Smerkova K, Skladanka J.  Animals (Basel). 2019 Jun 13;9(6). pii: E352. doi: 10.3390/ani9060352. Review.