Potential benefits of eicosapentaenoic acid on atherosclerotic plaques.
Nelson JR, Wani O, May HT, Budoff M
Vascul Pharmacol. 2017 Apr;91:1-9. doi: 10.1016/j.vph.2017.02.004. Epub 2017 Mar 2.

Eicosapentaenoic Acid Modulates Trichomonas vaginalis Activity.
Korosh T, Jordan KD, Wu JS, Yarlett N, Upmacis RK
J Eukaryot Microbiol. 2016 Mar-Apr;63(2):153-61. doi: 10.1111/jeu.12263. Epub 2015 Sep 23.

Research Progress on the Risk Factors and Outcomes of Human Carotid Atherosclerotic Plaques.
Xiong XD, Xiong WD, Xiong SS, Chen GH
Chin Med J (Engl). 2017 Mar 20;130(6):722-729. doi: 10.4103/0366-6999.201598.

The eicosapentaenoic acid:arachidonic acid ratio and its clinical utility in cardiovascular disease.
Nelson JR, Raskin S.
Postgrad Med. 2019 May 7:1-10.

Eicosapentaenoic acid suppresses angiogenesis via reducing secretion of IL‑6 and VEGF from colon cancer‑associated fibroblasts.
Ando N, Hara M, Shiga K, Yanagita T, Takasu K, Nakai N, Maeda Y, Hirokawa T, Takahashi H, Ishiguro H, Matsuo Y, Takiguchi S.
Oncol Rep. 2019 May 2. doi: 10.3892/or.2019.7141.

Clinical trials of eicosapentaenoic acid (EPA) prescription products for the treatment of hypertriglyceridemia.
Doggrell SA.
Expert Opin Pharmacother. 2019 Apr 30:1-5. doi: 10.1080/14656566.2019.1609942.

Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid. It is incorporated into mitochondrial membranes and can be effective as a pharmacological therapy to improve mitochondrial physiology in skeletal muscle aging (1).

It has a unique chemical structure with important biological consequences. By replacing the arachidonic omega-6 fatty acid in membrane phospholipids, EPA can alter the physical properties of cell membranes. Furthermore, its metabolism can give rise to anti-inflammatory and anti-thrombotic lipid mediators in contrast to pro-inflammatory and pro-thrombotic factors which tend to be produced by arachidonic acid (2).

EPA studies

Molecular Formula: C₂₀H₃₀O2

Molecular Weight: 302.45

CAS: 25378-27-2

References____________________________

(1) Eicosapentaenoic acid but not docosahexaenoic acid restores skeletal muscle mitochondrial oxidative capacity in old mice
Matthew L Johnson, Antigoni Z Lalia, Surendra Dasari, Maximilian Pallauf, Mark Fitch, Marc K Hellerstein, Ian R Lanza
Aging Cell. 2015 Oct; 14(5): 734–743. Published online 2015 May 25. doi: 10.1111/acel.12352

(2) Prescription omega-3 fatty acid products containing highly purified eicosapentaenoic acid (EPA)
Eliot A. Brinton and R. Preston Mason
Lipids Health Dis. 2017; 16: 23.
Published online 2017 Jan 31. doi:  10.1186/s12944-017-0415-8