Attenuation of diabetic nephropathy by dietary fenugreek (Trigonella foenum-graecum) seeds and onion (Allium cepa) via suppression of glucose transporters and renin-angiotensin system.
Pradeep SR, Barman S, Srinivasan K.
Nutrition. 2019 Jul 1;67-68:110543. doi: 10.1016/j.nut.2019.06.024.

Isolation, qualitative and quantitative evaluation of galactomannan during germination of Trigonella persica (Fabaceae) seed.
Bakhshy E, Zarinkamar F, Nazari M.
Int J Biol Macromol. 2019 Sep 15;137:286-295. doi: 10.1016/j.ijbiomac.2019.06.225.

A randomized controlled clinical trial evaluating the effect of Trigonella foenum-graecum (fenugreek) versus glibenclamide in patients with diabetes.
Najdi RA, Hagras MM, Kamel FO, Magadmi RM.
Afr Health Sci. 2019 Mar;19(1):1594-1601. doi: 10.4314/ahs.v19i1.34.

Diosgenin and Its Fenugreek Based Biological Matrix Affect Insulin Resistance and Anabolic Hormones in a Rat Based Insulin Resistance Model.
Kiss R, Pesti-Asbóth G, Szarvas MM, Stündl L, Cziáky Z, Hegedűs C, Kovács D, Badale A, Máthé E, Szilvássy Z, Remenyik J.
Biomed Res Int. 2019 Apr 4;2019:7213913. doi: 10.1155/2019/7213913

The Antidepressant-like Effect of Flavonoids from Trigonella Foenum-Graecum Seeds in Chronic Restraint Stress Mice via Modulation of Monoamine Regulatory Pathways.
Wang J, Cheng C, Xin C, Wang Z.
Molecules. 2019 Mar 20;24(6). pii: E1105. doi: 10.3390/molecules24061105.

Amebicidal effects of fenugreek (Trigonella foenum-graecum) against Acanthamoeba cysts.
Kaya Y, Baldemir A, Karaman Ü, Ildız N, Arıcı YK, Kaçmaz G, Kolören Z, Konca Y.
Food Sci Nutr. 2019 Jan 28;7(2):563-571. doi: 10.1002/fsn3.849.

Anti-obesity action of INDUS810, a natural compound from Trigonella foenum-graecum: AMPK-dependent lipolysis effect in adipocytes.
Cheng CY, Yang AJ, Ekambaranellore P, Huang KC, Lin WW.
Obes Res Clin Pract. 2018 Nov - Dec;12(6):562-569. doi: 10.1016/j.orcp.2018.08.005

Antioxidant and anticancer activities of Trigonella foenum-graecum, Cassia acutifolia and Rhazya stricta.
Al-Dabbagh B, Elhaty IA, Al Hrout A, Al Sakkaf R, El-Awady R, Ashraf SS, Amin A.
BMC Complement Altern Med. 2018 Aug 22;18(1):240. doi: 10.1186/s12906-018-2285-7

Evaluation of anti-arthritic potential of Trigonella foenum graecum L. (Fenugreek) mucilage against rheumatoid arthritis.
G S, G L S, Pushpan CK, Nambisan B, A H.
Prostaglandins Other Lipid Mediat. 2018 Sep;138:48-53. doi: 10.1016/j.prostaglandins.2018.08.002.

Fenugreek (Trigonella Foenum-Graecum) Seed Flour and Diosgenin Preserve Endothelium-Dependent Arterial Relaxation in a Rat Model of Early-Stage Metabolic Syndrome.
Szabó K, Gesztelyi R, Lampé N, Kiss R, Remenyik J, Pesti-Asbóth G, Priksz D, Szilvássy Z, Juhász B.
Int J Mol Sci. 2018 Mar 10;19(3). pii: E798. doi: 10.3390/ijms19030798.

Fenugreek (Trigonella foenum-graecum) is a plant belonging to the Fabaceae family.

It is found in India, China, East Africa and is also cultivated in Europe.

Fenugreek seeds contain phytonutrients as mucilage polysaccharides (galactomannan) and defence components as steroid saponins (with aglycones: diosgenin, yamogenin and tigogenin) (1).

In traditional medicine, the seed is used externally to treat furunculosis, eczema, ulcers and local skin inflammations administered locally or added to a hot bath (2).

Protein hydrolysates extracted from fenugreek could be used as nutraceutical molecules in colorectal cancer treatment (3).

Use in children and adolescents under the age of 18 is not recommended due to incomplete safety data (4).

Fenugreek studies

References_________________________________

(1) European Scientific Cooperative on Phytotherapy. Trigonellae foenugraeci semen. 2nd ed. New York: Thieme; 2003. ESCOP Monographs; pp. 511–20.

(2) WHO. Semen Trigonellae Foenugraeci. Geneva: World Health Organization; 2007. Monographs on selected medicinal plants; pp. 247–56.

(3) Protein Hydrolysates from Fenugreek (Trigonella foenum graecum) as Nutraceutical Molecules in Colon Cancer Treatment.  Allaoui A, Gascón S, Benomar S, Quero J, Osada J, Nasri M, Rodríguez-Yoldi MJ, Boualga A.  Nutrients. 2019 Mar 28;11(4). pii: E724. doi: 10.3390/nu11040724.

(4) EMEA. European Medicines Agency. Trigonella foenum-graecum L; London: Semen; 2010.