A relative assessment of essential oil of Chrysopogon zizanioides and Matricaria chamomilla along with calcium hydroxide and chlorhexidine gel against Enterococcus faecalis in ex vivo root canal models.
Shakya VK, Luqman S, Tikku AP, Chandra A, Singh DK.
J Conserv Dent. 2019 Jan-Feb;22(1):34-39. doi: 10.4103/JCD.JCD_69_18.

Isolation, functional characterization, and biological properties of MCh-AMP1, a novel antifungal peptide from Matricaria chamomilla L.
Seyedjavadi SS, Khani S, Zare-Zardini H, Halabian R, Goudarzi M, Khatami S, Imani Fooladi AA, Amani J, Razzaghi-Abyaneh M.
Chem Biol Drug Des. 2019 May;93(5):949-959. doi: 10.1111/cbdd.13500

Antioxidant and anticancer activities of chamomile (Matricaria recutita L.).
Al-Dabbagh B, Elhaty IA, Elhaw M, Murali C, Al Mansoori A, Awad B, Amin A.
BMC Res Notes. 2019 Jan 3;12(1):3. doi: 10.1186/s13104-018-3960-y.

Biomimetic synthesis of silver nanoparticles using Matricaria chamomilla extract and their potential anticancer activity against human lung cancer cells.
Dadashpour M, Firouzi-Amandi A, Pourhassan-Moghaddam M, Maleki MJ, Soozangar N, Jeddi F, Nouri M, Zarghami N, Pilehvar-Soltanahmadi Y.
Mater Sci Eng C Mater Biol Appl. 2018 Nov 1;92:902-912. doi: 10.1016/j.msec.2018.07.053.

Matricaria genus as a source of antimicrobial agents: From farm to pharmacy and food applications.
Sharifi-Rad M, Nazaruk J, Polito L, Morais-Braga MFB, Rocha JE, Coutinho HDM, Salehi B, Tabanelli G, Montanari C, Del Mar Contreras M, Yousaf Z, Setzer WN, Verma DR, Martorell M, Sureda A, Sharifi-Rad J.
Microbiol Res. 2018 Oct;215:76-88. doi: 10.1016/j.micres.2018.06.010. Epub 2018 Jun 25. Review.

Effects of Matricaria Recutita (L.) in the Treatment of Oral Mucositis.
Gomes VTS, Nonato Silva Gomes R, Gomes MS, Joaquim WM, Lago EC, Nicolau RA.
ScientificWorldJournal. 2018 Jun 12;2018:4392184. doi: 10.1155/2018/4392184

Experimental and clinical antihypertensive activity of Matricaria chamomilla extracts and their angiotensin-converting enzyme inhibitory activity.
Awaad AA, El-Meligy RM, Zain GM, Safhi AA, Al Qurain NA, Almoqren SS, Zain YM, Sesh Adri VD, Al-Saikhan FI.
Phytother Res. 2018 Aug;32(8):1564-1573. doi: 10.1002/ptr.6086.

Effectiveness of Matricaria chamomilla (chamomile) extract on pain control of cyclic mastalgia: a double-blind randomised controlled trial.
Saghafi N, Rhkhshandeh H, Pourmoghadam N, Pourali L, Ghazanfarpour M, Behrooznia A, Vafisani F.
J Obstet Gynaecol. 2018 Jan;38(1):81-84. doi: 10.1080/01443615.2017.1322045.

Chamomilla recutita or Matricaria recutita or Matricaria chamomila (Chamomile) is herbal medicinal plant of 15 to 50 cm high and from planting stage it flowers, after a few weeks.

Chamomile flowers contain phenolic compounds e.g flavonoides such as a glycogen, apigenin, flavon glycoside and luteoline.

Matricaria chamomila is used to relief various body pain, calm headaches and tooth aches.

This experimental and dose-response curve study aimed to carry out the quality control of the Chamomilla recutita sample, as well as to estimate the ideal dose, for anti-inflammatory effect, of the extract of its capitula, in patients with phlebitis due to peripheral intravenous infusion of antineoplastic chemotherapy and to evaluate the toxicity of this extract in human beings. The therapeutic efficacy, concerning the anti-inflammatory potential, of different doses of Chamomilla recutita extract were analyzed and compared in 25 patients. The time of regression of phlebitis was shorter for groups with 2.5% concentration (mean=29.2h, standard deviation = 8.98) and 5% concentration (mean = 38.8h, standard deviation = 17.47). Local toxicity was almost not observed. This research contributes to the innovation of the nursing clinical practice, since it suggests an alternative for the treatment of phlebitis through the clinical use of phytotherapeutic drugs.(ClinicalTrials.gov Identifier: NCT 00989599) (1).

Oral mucositis is a common inflammatory complication among patients undergoing hematopoietic stem cell transplantation (HSCT). Among its therapeutic properties, Chamomilla recutita has anti-inflammatory effects.The experimental group at the 1% dosage demonstrated reduced incidence, intensity, and duration of oral mucositis compared with the control group. The formulation was well tolerated by patients and was safe, as no moderate or severe adverse effects were identified (2).

Chamomilla recutita studies

References______________________________________________________________________

(1) Braga FT, Santos AC, Bueno PC, Silveira RC, Santos CB, Bastos JK, Carvalho EC. Use of Chamomilla recutita in the Prevention and Treatment of Oral Mucositis in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Randomized, Controlled, Phase II Clinical Trial. Cancer Nurs. 2015 Jul-Aug;38(4):322-9. doi: 10.1097/NCC.0000000000000194. 

(2) Reis PE, Carvalho EC, Bueno PC, Bastos JK. Clinical application of Chamomilla recutita in phlebitis: dose response curve study. Rev Lat Am Enfermagem. 2011 Jan-Feb;19(1):3-10. doi: 10.1590/s0104-11692011000100002.