Environmentally Benign and Facile Process for the Synthesis of Pantoprazole Sodium Sesquihydrate: Phase Transformation of Pantoprazole Sodium Heterosolvate to Pantoprazole Sodium Sesquihydrate. n Awasthi AK, Kumar L, Tripathi P, Golla M, Aga MA, Reddy CS, Kumar P.  ACS Omega. 2017 Sep 6;2(9):5460-5469. doi: 10.1021/acsomega.7b00743.

Prospects to the formation and control of potential dimer impurity E of pantoprazole sodium sesquihydrate.  Awasthi AK, Kumar L, Tripathi P, Golla M, Reddy CS, Kumar P.  J Pharm Anal. 2019 Jun;9(3):170-177. doi: 10.1016/j.jpha.2019.02.002

On the Mechanism of Formation and the Synthesis of Pantoprazole Sodium Sesquihydrate-Related Compound E: A Phantom Chemical Entity.  Yari A, Zolali A, Karimian K.  ACS Omega. 2019 Jan 9;4(1):737-744. doi: 10.1021/acsomega.8b00845.

Physical characterization of pantoprazole sodium hydrates.  Zupancic V, Ograjsek N, Kotar-Jordan B, Vrecer F.  Int J Pharm. 2005 Mar 3;291(1-2):59-68.

A novel quantification method of pantaprazole sodium monohydrate in sesquihydrate by thermogravimetric analyzer.  Reddy VR, Rajmohan MA, Shilpa RL, Raut DM, Naveenkumar K, Suryanarayana MV, Mathad VT.  J Pharm Biomed Anal. 2007 Apr 11;43(5):1836-41.

Reversed-phase high performance liquid chromatographic method for the determination of lansoprazole, omeprazole and pantoprazole sodium sesquihydrate in presence of their Acid-induced degradation products.  El-Sherif ZA, Mohamed AO, El-Bardicy MG, El-Tarras MF.  Chem Pharm Bull (Tokyo). 2006 Jun;54(6):814-8.

In the scientific literature, two forms of pantoprazole are treated: mono and sesquidrate.

Pantoprazole sodium sesquihydrate is used as a proton pump inhibitor, as a potent inhibitor of gastric acid secretion and is widely used for the treatment of gastroesophageal reflux, dyspepsia and peptic ulcer.

It also exerts an anti-inflammatory action (1) in gastric and endothelial parietal cells.

The increase in the number of drugs containing pantoprazole sodium sesquihydrate raises questions about its effectiveness and generic substitutability. This study examined 6 generic drugs and performed a series of tests to monitor their efficacy as pantoprazole becomes unstable at low pH values (2).

Like all drugs it can cause side effects. Always consult your doctor.

Pantoprazole sodium sesquihydrate studies

Molecular Formula: C₃₂H₃₄F₄N₆Na₂O₁₁S₂

Molecular  Weight: 864.8 g/mol

CAS: 164579-32-2

EC Number: 605-368-1

Synonyms:

• Pantoprazole sodium hydrate
• Protonix (TN)
• disodium 5-(difluoromethoxy)-2-[(3,4-dimethoxy-2-pyridyl)methylsulfinyl]benzimidazol-1-ide trihydrate
• disodium;5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]benzimidazol-1-ide;trihydrate

References_________________________________________________

(1) Pantoprazole, an FDA-approved proton-pump inhibitor, suppresses colorectal cancer growth by targeting T-cell-originated protein kinase.  Zeng X, Liu L, Zheng M, Sun H, Xiao J, Lu T, Huang G, Chen P, Zhang J, Zhu F, Li H, Duan Q  Oncotarget. 2016 Apr 19; 7(16):22460-73.

(2) Assessment of the pharmaceutical quality of marketed enteric coated pantoprazole sodium sesquihydrate products.  Mostafa HF, Ibrahim MA, Mahrous GM, Sakr A.  Saudi Pharm J. 2011 Apr;19(2):123-7. doi: 10.1016/j.jsps.2011.01.001.