Neonatal effects of intrauterine metoprolol/bisoprolol exposure during the second and third trimester: a cohort study with two comparison groups.
Kayser A, Beck E, Hoeltzenbein M, Zinke S, Meister R, Weber-Schoendorfer C, Schaefer C.
J Hypertens. 2019 Oct 3. doi: 10.1097/HJH.0000000000002256

Effects of carvedilol vs bisoprolol on inflammation and oxidative stress in patients with chronic heart failure.
Toyoda S, Haruyama A, Inami S, Arikawa T, Saito F, Watanabe R, Sakuma M, Abe S, Nakajima T, Tanaka A, Node K, Inoue T.
J Cardiol. 2019 Aug 21. pii: S0914-5087(19)30237-0. doi: 10.1016/j.jjcc.2019.07.011.

Carvedilol and bisoprolol as initial therapy for adult hypertension without compelling indications.
Kishi T, Fujii E.
Hypertens Res. 2019 Apr;42(4):496-503. doi: 10.1038/s41440-018-0174-6.

Long-term effectiveness of bisoprolol in patients with angina: A real-world evidence study.
Sabidó M, Thilo H, Guido G.
Pharmacol Res. 2019 Jan;139:106-112. doi: 10.1016/j.phrs.2018.10.031.

Bisoprolol Successfully Improved the Intraventricular Pressure Gradient in a Patient with Midventricular Obstructive Hypertrophic Cardiomyopathy with an Apex Aneurysm due to Apical Myocardial Damage.
Tezuka A, Higo K, Nakamukae Y, Nishihara S, Kamikawa M, Shimofuku C, Kawazoe K, Ohishi M.
Intern Med. 2019 Feb 15;58(4):535-539. doi: 10.2169/internalmedicine.0997-18.

Bioequivalence and Pharmacokinetics of Bisoprolol-Amlodipine 5 mg/5 mg Combination Tablet versus Bisoprolol 5 mg Tablet and Amlodipine 5 mg Tablet: An Open-Label, Randomized, Two-Sequence Crossover Study in Healthy Chinese Subjects.
Hu C, Hu X, Wang C, Zhao Z, Gao D, Chen X, Zhou D, Huang Y, Li L, Zhang L.
Clin Drug Investig. 2018 Dec;38(12):1145-1154. doi: 10.1007/s40261-018-0700-y.

Bisoprolol Transdermal Patch Is Effective for the Treatment of AF Tachycardia.
Arita Y, Saeki H, Miyoshi M, Hasegawa S.
Case Rep Cardiol. 2018 May 21;2018:9139302. doi: 10.1155/2018/9139302

Impact of Heart Rate Reduction with Maximal Tolerable Dose of Bisoprolol on Left Ventricular Reverse Remodeling.
Choi SW, Han S, Shim WJ, Choi DJ, Kim YJ, Yoo BS, Hwang KK, Jeon HK, Shin MS, Ryu KH.
J Korean Med Sci. 2018 May 11;33(25):e171. doi: 10.3346/jkms.2018.33.e171

Effects of Bisoprolol Are Comparable with Carvedilol in Secondary Prevention of Acute Myocardial Infarction in Patients Undergoing Percutaneous Coronary Intervention.
Jun SJ, Kim KH, Jeong MH, Kim MC, Sim DS, Hong YJ, Kim JH, Cho MC, Chae JK, Park HS, Park JS, Ahn YK.
Chonnam Med J. 2018 May;54(2):121-128. doi: 10.4068/cmj.2018.54.2.121

Sympathetic Nervous System Activation in Pathogenesis of Development of Essential Hypertension and Its Role in Target-Organs Damage in Young and Middle Aged Adults: the Cardioprotective Capabilities of Bisoprolol.
Ostroumova OD, Kochetkov AI, Guseva TF, Zykova AA.
Kardiologiia. 2018 Mar;(3):63-72.

Efficacy of Propranolol, Bisoprolol, and Pyridostigmine for Postural Tachycardia Syndrome: a Randomized Clinical Trial.
Moon J, Kim DY, Lee WJ, Lee HS, Lim JA, Kim TJ, Jun JS, Park B, Byun JI, Sunwoo JS, Lee ST, Jung KH, Park KI, Jung KY, Kim M, Lee SK, Chu K.
Neurotherapeutics. 2018 Jul;15(3):785-795. doi: 10.1007/s13311-018-0612-9.

Efficacy and Safety of Switching From Oral Bisoprolol to Transdermal Patch in Japanese Patients With Chronic Heart Failure.
Momomura SI, Saito Y, Yasumura Y, Yamamoto K, Sakata Y, Daimon M, Kinugawa K, Okamoto H, Dohi N, Komuro I.
Circ J. 2017 Dec 25;82(1):141-147. doi: 10.1253/circj.CJ-17-0532.

Comparison of efficacy and safety between bisoprolol transdermal patch (TY-0201) and bisoprolol fumarate oral formulation in Japanese patients with grade I or II essential hypertension: randomized, double-blind, placebo-controlled study.
Matsuoka H, Kuwajima I, Shimada K, Mitamura H, Saruta T.
J Clin Hypertens (Greenwich). 2013 Nov;15(11):806-14. doi: 10.1111/jch.12208.

Bisoprolol, a derivative of phenoxy-2-propanol, is a drug widely used to treat chronic heart failure as a free base or conjugate base of bisoprolole-fumarate in transdermal, tablet form.

It is a beta-blocker also used in the treatment of hypertension, atrial fibrillation, postural tachycardia syndrome, angina and arrhythmia.

Antihypertensive drugs in the form of transdermal patches in particular are considered clinically significant as they allow stable control of diastolic pressure (1).

It exerts an antioxidant activity and, due to its lipophilic nature, facilitates the passage in the brain tissue to produce therapeutic actions on central neurons (2).

In a comparison, the tolerability, effectiveness and safety of bisoprolol and carvedilol do not show significant differences (3).

Like all drugs it can cause side effects. Always consult your doctor.

Bisoprolol studies

Molecular Formula: C₁₈H₃₁NO₄

Molecular  Weight: 325.4 g/mol

CAS: 66722-44-9

EC Number: 615-996-8

DSSTox Substance ID: DTXSID6022682

MDL number MFCD00865795

PubChem Substance ID 329757631

Synonyms:

• Bisoprololum
• Cardicor
• Bisocor
• Detensiel
• Emconcor
• Euradal
• Soloc
• Monocor
• Emcor
• Isoten
• Soprol
• 1-(4-((2-isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-2-ol
• [2-hydroxy-3-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxy)propyl](propan-2-yl)amine
• (+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol
• (RS)-1-(4-(2-Isopropoxyethoxymethyl)phenoxy)-3-(isopropylamino)-2-propanol
• 1-{4-[(2-isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)propan-2-ol
• 1-[(1-methylethyl)amino]-3-({4-[({2-[(1-methylethyl)oxy]ethyl}oxy)methyl]phenyl}oxy)propan-2-ol
• 1-(propan-2-ylamino)-3-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxy)propan-2-ol
• 1-(4-[(2-Isopropoxyethoxy)methyl]phenoxy)-3-(isopropylamino)-2-propanol #
• 2-Propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-
• 1-[4-(2-isopropoxyethoxymethyl)phenoxy]-3-(isopropylamino)propan-2-ol
• 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-
• (.+/-.)-1-[[.alpha.-(2-Isopropoxyethoxy)-p-tolyl]oxy]-3-(isopropylamino)-2-propanol
• 2-Propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-
• 3-(4-{[2-(methylethoxy)ethoxy]methyl}phenoxy)-1-[(methylethyl)amino]propan-2-o l

References_________________________________________________

(1) EFFECT OF HYDROPHILIC AND HYDROPHOBIC POLYMER ON IN VITRO DISSOLUTION AND PERMEATION OF BISOPROLOL FUMARATE THROUGH TRANSDERMAL PATCH.  Shabbir M, Ali S, Raza M, Sharif A, Akhtar FM, Manan A, Fazli AR, Younas N, Manzoor I.  Acta Pol Pharm. 2017 Jan;74(1):187-197.

(2) Quantification of Bisoprolol and Metoprolol in Simultaneous Human Serum and Cerebrospinal Fluid Samples.  Sigaroudi A, Kinzig M, Wahl O, Stelzer C, Schroeter M, Fuhr U, Holzgrabe U, Sörgel F.  Pharmacology. 2018;101(1-2):29-34. doi: 10.1159/000480091.

(3) Tolerability, Efficacy, and Safety of Bisoprolol vs. Carvedilol in Japanese Patients With Heart Failure and Reduced Ejection Fraction　- The CIBIS-J Trial.  Tsutsui H, Momomura SI, Masuyama T, Saito Y, Komuro I, Murohara T, Kinugawa S; CIBIS-J Investigators.  Circ J. 2019 May 24;83(6):1269-1277. doi: 10.1253/circj.CJ-18-1199.