Latest studies

Randomized, Placebo-controlled Study of a Nutraceutical Based on Hyaluronic Acid, L-carnosine, and Methylsulfonylmethane in Facial Skin Aesthetics and Well-being.  Guaitolini E, Cavezzi A, Cocchi S, Colucci R, Urso SU, Quinzi V.  J Clin Aesthet Dermatol. 2019 Apr;12(4):40-45.

Long-Term Exposure of Psoralen and Isopsoralen Induced Hepatotoxicity and Serum Metabolites Profiles Changes in Female Rats.  Yu Y, Wang P, Yu R, Lu J, Jiang M, Zhou K.  Metabolites. 2019 Nov 2;9(11). pii: E263. doi: 10.3390/metabo9110263.

Two-site jumps in dimethyl sulfone studied by one- and two-dimensional 17O NMR spectroscopy.  Beerwerth J, Storek M, Greim D, Lueg J, Siegel R, Cetinkaya B, Hiller W, Zimmermann H, Senker J, Böhmer R.  J Magn Reson. 2018 Mar;288:84-94. doi: 10.1016/j.jmr.2018.01.016.

Comparison and evaluation of the quick purification methods of methamphetamine hydrochloride from dimethyl sulfone for spectroscopic identification.  Segawa H, Kumisaka K, Sugita R, Iwata YT, Yamamuro T, Kuwayama K, Tsujikawa K, Kanamori T, Inoue H.  Forensic Sci Int. 2018 Jan;282:86-91. doi: 10.1016/j.forsciint.2017.11.016.

Methylsulfonylmethane (MSM): A chemical shift reference for 1 H MRS of human brain.  Kaiser LG, Russell D, Maschmeyer T, Redfern RL, Inglis BA.  Magn Reson Med. 2020 Apr;83(4):1157-1167. doi: 10.1002/mrm.27997. 

Methylsulfonylmethane exhibits bacteriostatic inhibition of Escherichia coli, and Salmonella enterica Kinshasa, in vitro.  Poole TL, Benjamin R, Genovese KJ, Nisbet DJ.  J Appl Microbiol. 2019 Dec;127(6):1677-1685. doi: 10.1111/jam.14446.

Methylsulfonylmethane for treatment of low back pain: A safety analysis of a randomized, controlled trial.  Crawford P, Crawford A, Nielson F, Lystrup R.  Complement Ther Med. 2019 Aug;45:85-88. doi: 10.1016/j.ctim.2019.05.022

Evaluating the Impacts of Methylsulfonylmethane on Allergic Rhinitis After a Standard Allergen Challenge: Randomized Double-Blind Exploratory Study.  Hewlings S, Kalman DS.  JMIR Res Protoc. 2018 Nov 29;7(11):e11139. doi: 10.2196/11139.

Methylsulfonylmethane decreases inflammatory response to tumor necrosis factor-α in cardiac cells.  Miller LE.  Am J Cardiovasc Dis. 2018 Jun 15;8(3):31-38

Protective effect of methylsulfonylmethane in caerulein-induced acute pancreatitis and associated lung injury in mice.  Velusamy RK, Tamizhselvi R.  J Pharm Pharmacol. 2018 Sep;70(9):1188-1199. doi: 10.1111/jphp.12946

Methylsulfonylmethane or Dimethyl sulfone or MSM is an organic compound sulphur-containing that belongs to a class of chemical components called sulfones and is used as a dietary supplement to improve the signs of aging.

It's a metabolite found in human cerebrospinal fluid and blood plasma. It comes from food sources such as fruits, vegetables, cereals, milk, the metabolism of human endogenous methanetiol and intestinal bacterial metabolism (1).

This study has shown that methylsulfonylmethane is effective in reducing visual signs of skin aging even at low doses of 1 g/d. (2).

It is a potential drug for the inhibition of cortisol (cortisol is a hormone involved in stress during exercise) in the skeletal muscle cells of racehorses (3).

Methylsulfonylmethane could promote differentiation and osteogenic potential of stem cells from exfoliated deciduous human dental cells. This osteogenic property is most evident in the presence of mineralized bone particles (4).

MSM in a low dose (200 mM) is able to reduce the migration and invasion of prostate cancer cells (5).

Methylsulfonylmethane. What scientific research says

Molecular Formula: C₂H₆O₂S

Molecular Weight: 325.4 g/mol

CAS: 67-71-0

EC Number: 200-665-9

DSSTox Substance ID: DTXSID4043937

UNII 9H4PO4Z4FT 

Synonyms: 

• Dimethyl sulphone
• methylsulfone
• Sulfonylbismethane
• Methane, sulfonylbis-
• sulfonyldimethane
• 2-Thiapropane2,2-dioxide
• 2-methylthioacetic acid ethylester

References_________________________________________________

(1) Dimethyl sulfone in human cerebrospinal fluid and blood plasma confirmed by one-dimensional (1)H and two-dimensional (1)H-(13)C NMR.  Engelke UF, Tangerman A, Willemsen MA, Moskau D, Loss S, Mudd SH, Wevers RA.  NMR Biomed. 2005 Aug;18(5):331-6.

(2) Beauty from within: Oral administration of a sulfur-containing supplement methylsulfonylmethane improves signs of skin ageing.  Muizzuddin N, Benjamin R.  Int J Vitam Nutr Res. 2020 Feb 21:1-10. doi: 10.1024/0300-9831/a000643.

(3) Methylsulfonylmethane inhibits cortisol-induced stress through p53-mediated SDHA/HPRT1 expression in racehorse skeletal muscle cells: A primary step against exercise stress.  Sp N, Kang DY, Kim DH, Lee HG, Park YM, Kim IH, Lee HK, Cho BW, Jang KJ, Yang YM.  Exp Ther Med. 2020 Jan;19(1):214-222. doi: 10.3892/etm.2019.8196.

(4) Methylsulfonylmethane increases osteogenesis and regulates the mineralization of the matrix by transglutaminase 2 in SHED cells.  Aljohani H, Senbanjo LT, Chellaiah MA.  PLoS One. 2019 Dec 5;14(12):e0225598. doi: 10.1371/journal.pone.0225598.

(5) Methylsulfonylmethane (organic sulfur) induces apoptosis and decreases invasiveness of prostate cancer cells. Kowalska K, Habrowska-Górczyńska DE, Domińska K, Urbanek KA, Piastowska-Ciesielska AW.  Environ Toxicol Pharmacol. 2018 Dec;64:101-111. doi: 10.1016/j.etap.2018.10.001.