The in-depth studies on Hederagenin cover the latest studies on its applications and its availability.

Del Hierro JN, Cueva C, Tamargo A, et al. In Vitro Colonic Fermentation of Saponin-Rich Extracts from Quinoa, Lentil, and Fenugreek. Effect on Sapogenins Yield and Human Gut Microbiota. J Agric Food Chem. 2020;68(1):106–116. doi:10.1021/acs.jafc.9b05659

El Hazzam K, Hafsa J, Sobeh M, et al. An Insight into Saponins from Quinoa (Chenopodium quinoa Willd): A Review. Molecules. 2020;25(5):E1059. Published 2020 Feb 27. doi:10.3390/molecules25051059

Rodríguez-Hernández D, Barbosa LCA, Demuner AJ, Ataide Martins JP, Fischer Nee Heller L, Csuk R. Hederagenin amide derivatives as potential antiproliferative agents. Eur J Med Chem. 2019;168:436–446. doi:10.1016/j.ejmech.2019.02.057

Wu R, Dong S, Cai FF, et al. Active Compounds Derived from Fuzheng Huayu Formula Protect Hepatic Parenchymal Cells from Apoptosis Based on Network Pharmacology and Transcriptomic Analysis. Molecules. 2019;24(2):338. Published 2019 Jan 18. doi:10.3390/molecules24020338

Mireku EA, Mensah AY, Amponsah IK, Danquah CA, Anokwah D, Kwesi Baah M. Antimicrobial pentacyclic triterpenes and glycosides from the stem bark of Cussonia bancoensis. Nat Prod Res. 2020;34(6):859–862. doi:10.1080/14786419.2018.1503262

Fang K, Zhang XH, Han YT, et al. Design, Synthesis, and Cytotoxic Analysis of Novel Hederagenin⁻Pyrazine Derivatives Based on Partial Least Squares Discriminant Analysis. Int J Mol Sci. 2018;19(10):2994. Published 2018 Sep 30. doi:10.3390/ijms19102994

Ma XL, Li WX, Wang D, Lu FP, Dai ZB, Zhang XL. Biosynthesis Analysis of Hederagenin Pathway and Its Construction in Yeast Cells Zhongguo Zhong Yao Za Zhi. 2018;43(9):1844–1850. doi:10.19540/j.cnki.cjcmm.20180307.008

Kim EH, Baek S, Shin D, Lee J, Roh JL. Hederagenin Induces Apoptosis in Cisplatin-Resistant Head and Neck Cancer Cells by Inhibiting the Nrf2-ARE Antioxidant Pathway. Oxid Med Cell Longev. 2017;2017:5498908. doi:10.1155/2017/5498908

Hederagenin is a pentacyclic triterpenoid, monocarboxylic dihydroxy acid and sapogenin. It comes from an oleanolic acid.

It is found in ivy (Hedera helix L.) and many plants (Lonicera fulvotomentosa, Paeonia Ostii, Akebiae Caulis, Momordica cochinchinensis, Crossopteryx Febrifuga, Caulophyllum robustum, Medicago truncatula, Chenopodium Quinoa, Blighia unijugata, Achyranthes bidentate, Cussonia bancoensis, Clematidis Radix).

The scientific literature attributes it a wide range of properties such as anti-inflammatory, antidepressant, hepatoprotective (1).    

Hederagenin inhibits proliferation and facilitates apoptosis of cervical cancer cells by inhibition of the STAT3 signaling pathway (1).

Hederagenin in-depth studies

Molecular Formula: C₃₀H₄₈O₄

Molecular Weight: 472.7 g/mol

CAS: 465-99-6

UNII RQF57J8212

EC Number: 207-369-9

MDL number MFCD00017385
 
NACRES NA.25

Sinonimi:

• 3,23-Dihydroxyolean-12-en-28-acid
• Astrantiagenin E
• Caulosapogenin
• Hederagenic acid
• Hederagenol

References________________________________________________________________________

(1) Ma XL, Li WX, Wang D, Lu FP, Dai ZB, Zhang XL. Biosynthesis Analysis of Hederagenin Pathway and Its Construction in Yeast Cells Zhongguo Zhong Yao Za Zhi. 2018;43(9):1844–1850. doi:10.19540/j.cnki.cjcmm.20180307.008

(2) Fang L, Liu M, Cai L. Hederagenin Inhibits Proliferation and Promotes Apoptosis of Cervical Cancer CaSki Cells by Blocking STAT3 Pathway. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2019;35(2):140–145.