Compendium of the most significant studies with reference to properties, intake, effects.

Cipriani A, La Ferla T, Furukawa TA, Signoretti A, Nakagawa A, Churchill R, McGuire H, Barbui C. Sertraline versus other antidepressive agents for depression. Cochrane Database Syst Rev. 2010 Apr 14;(4):CD006117. doi: 10.1002/14651858.CD006117.pub4. 

Cuomo A, Maina G, Neal SM, De Montis G, Rosso G, Scheggi S, Beccarini Crescenzi B, Bolognesi S, Goracci A, Coluccia A, Ferretti F, Fagiolini A. Using sertraline in postpartum and breastfeeding: balancing risks and benefits. Expert Opin Drug Saf. 2018 Jul;17(7):719-725. doi: 10.1080/14740338.2018.1491546.

Walkup JT, Albano AM, Piacentini J, Birmaher B, Compton SN, Sherrill JT, Ginsburg GS, Rynn MA, McCracken J, Waslick B, Iyengar S, March JS, Kendall PC. Cognitive behavioral therapy, sertraline, or a combination in childhood anxiety. N Engl J Med. 2008 Dec 25;359(26):2753-66. doi: 10.1056/NEJMoa0804633.

Yonkers KA, Kornstein SG, Gueorguieva R, Merry B, Van Steenburgh K, Altemus M. Symptom-Onset Dosing of Sertraline for the Treatment of Premenstrual Dysphoric Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2015 Oct;72(10):1037-44. doi: 10.1001/jamapsychiatry.2015.1472. 

Paulzen M, Goecke TW, Stickeler E, Gründer G, Schoretsanitis G. Sertraline in pregnancy - Therapeutic drug monitoring in maternal blood, amniotic fluid and cord blood. J Affect Disord. 2017 Apr 1;212:1-6. doi: 10.1016/j.jad.2017.01.019.

Brawman-Mintzer O, Knapp RG, Rynn M, Carter RE, Rickels K. Sertraline treatment for generalized anxiety disorder: a randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 2006 Jun;67(6):874-81. doi: 10.4088/jcp.v67n0603.

O'Connor CM, Jiang W, Kuchibhatla M, Silva SG, Cuffe MS, Callwood DD, Zakhary B, Stough WG, Arias RM, Rivelli SK, Krishnan R; SADHART-CHF Investigators. Safety and efficacy of sertraline for depression in patients with heart failure: results of the SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) trial. J Am Coll Cardiol. 2010 Aug 24;56(9):692-9. doi: 10.1016/j.jacc.2010.03.068.

Glassman AH, O'Connor CM, Califf RM, Swedberg K, Schwartz P, Bigger JT Jr, Krishnan KR, van Zyl LT, Swenson JR, Finkel MS, Landau C, Shapiro PA, Pepine CJ, Mardekian J, Harrison WM, Barton D, Mclvor M; Sertraline Antidepressant Heart Attack Randomized Trial (SADHEART) Group. Sertraline treatment of major depression in patients with acute MI or unstable angina. JAMA. 2002 Aug 14;288(6):701-9. doi: 10.1001/jama.288.6.701.

Gasparyan A, Navarrete F, Manzanares J. The administration of sertraline plus naltrexone reduces ethanol consumption and motivation in a long-lasting animal model of post-traumatic stress disorder. Neuropharmacology. 2021 Apr 2:108552. doi: 10.1016/j.neuropharm.2021.108552.

Mu C, Peng RK, Guo CL, Li A, Yang XM, Zeng R, Li YL, Gu J, Ouyang Q. Discovery of sertraline and its derivatives able to combat drug-resistant gastric cancer cell via inducing apoptosis. Bioorg Med Chem Lett. 2021 Mar 26;41:127997. doi: 10.1016/j.bmcl.2021.127997.

Marshall LL, Hayslett RL. Post-traumatic Stress Disorder in Middle Age and Beyond. Sr Care Pharm. 2021 Apr 1;36(4):191-206. doi: 10.4140/TCP.n.2021.191. 

Heinonen E, Blennow M, Blomdahl-Wetterholm M, Hovstadius M, Nasiell J, Pohanka A, Gustafsson LL, Wide K. Sertraline concentrations in pregnant women are steady and the drug transfer to their infants is low. Eur J Clin Pharmacol. 2021 Mar 22. doi: 10.1007/s00228-021-03122-z.

Javidi H, Ah-Moye S, Hennings C, Mehta H, Mahmood S. Presumed Sertraline-Associated Maculopathy: A Case Series. Ophthalmol Ther. 2021 Mar 20. doi: 10.1007/s40123-021-00340-7. 

Take only under medical supervision

Sertraline, a derivative of naphthalemine, is used to treat depressive disorders such as panic disorder, post-traumatic stress disorder, and obsessive-compulsive disorder.

Sertraline has minimal inhibitory effects on the major cytochrome P450 enzymes, and few drug-drug interactions of clinical significance have been documented. Like other selective serotonin reuptake inhibitors, sertraline is well tolerated in therapeutic dosages and relatively safe in overdosage. (1)

Sertraline is bound to blood proteins and albumin.

The in vivo metabolism of sertraline in humans has not yet been studied. variants in a number of genes involved in the sertraline pharmacokinetics and pharmacodynamics appear to affect its metabolism and clinical response. (2)

Regarding extraction methods, this study shows the advantages and disadvantages of extraction techniques in terms of extraction efficiency and precision and also discusses protein precipitation as one of the latest methods of sample purification. In presenting the final determination techniques, i.e., HPLC, LC, and GC, the study focuses on the type of detector (UV, nitrate-phosphate, MS) as a basic factor determining sensitivity, expressed as detection and quantification limits achieved by a given method. (3)

References____________________________________________________________

(1) DeVane CL, Liston HL, Markowitz JS. Clinical pharmacokinetics of sertraline. Clin Pharmacokinet. 2002;41(15):1247-66. doi: 10.2165/00003088-200241150-00002. 

(2) Huddart R, Hicks JK, Ramsey LB, Strawn JR, Smith DM, Bobonis Babilonia M, Altman RB, Klein TE. PharmGKB summary: sertraline pathway, pharmacokinetics. Pharmacogenet Genomics. 2020 Feb;30(2):26-33. doi: 10.1097/FPC.0000000000000392.

(3) Dziurkowska E, Wesolowski M. Sertraline - isolation methods and quantitation in biological material. Psychiatr Pol. 2018 Dec 29;52(6):997-1012. English, Polish. doi: 10.12740/PP/85788.