Sodium cyclamate is a chemical compound, the sodium salt of cyclamic acid produced by chemical synthesis with cyclohexane and sulphamic acid as raw materials.The name describes the structure of the moleculeSodium indicates the presence of sodium ions (Na). In the context of sweeteners, sodium is used to form salts with organic compounds.... (Read the full Tiiip)
Sodium cyclamate is a chemical compound, the sodium salt of cyclamic acid produced by chemical synthesis with cyclohexane and sulphamic acid as raw materials.The name describes the structure of the mo ...
Sodium cyclamate is a chemical compound, the sodium salt of cyclamic acid produced by chemical synthesis with cyclohexane and sulphamic acid as raw materials.
The name describes the structure of the molecule
Sodium indicates the presence of sodium ions (Na). In the context of sweeteners, sodium is used to form salts with organic compounds.
Cyclamate is an organic compound known for its sweetening properties that is many times sweeter than table sugar (sucrose) but has a lower calorie contribution.
Raw materials used in production.
Cyclohexane - Cyclohexane is a cyclic hydrocarbon used as a raw material in the synthesis of sodium cyclamate.
Sulfamic Acid - Sulfamic acid is a chemical substance used in the synthesis reaction to produce sodium cyclamate.
Step-by-step summary of industrial chemical synthesis process
Preparation of Raw Materials - Cyclohexane and sulfamic acid are prepared and purified as raw materials.
Synthesis of Sodium Cyclamate - Cyclohexane and sulfamic acid are reacted in a controlled chemical reaction to produce sodium cyclamate. This chemical reaction involves the formation of a bond between sulfamic acid and cyclohexane, creating the chemical structure of sodium cyclamate.
Crystallization and Purification - The resulting sodium cyclamate is crystallized and purified to remove impurities and obtain the final product.
Sodium cyclamate is typically available in the form of white crystals or powder.
What it is used for and where
Sodium Cyclamate is commonly used in foods and beverages as a sugar substitute to reduce calorie intake. It is particularly popular in diet and diabetic products. However, the use of sodium cyclamate is subject to regulation and restrictions in some countries due to safety concerns.
Food
Ingredient included in the list of European food additives as E952
Used as a non-nutritive sweetener with a sweetening capacity of 30 to 50 times more than sugar in a wide variety of food products: Bakery products, Desserts, Cakes, Jellies, Confectionery, Biscuits, Compound condiments, Table sweeteners, Fruit preserves, Jams and marmalades, Chewing gum, Pickled vegetables, Preserved fruit, etc. It is labelled with the number E959 in the list of European food additives.
Cosmetics
Fragrance. It plays a decisive and important role in the formulation of cosmetic products as it provides the possibility of enhancing, masking or adding fragrance to the final product, increasing its marketability. It is able to create a perceptible pleasant odour, masking a bad smell. The consumer always expects to find a pleasant or distinctive scent in a cosmetic product.
Studies
This study investigated the effects of the commonly used dietary sweetener sodium cyclamate on osteoblast proliferation and differentiation. The results indicate that a very low concentration (0.06 μM) of sodium cyclamate can curl and fold microfilament and microtubule of osteoblasts. The addition of sodium cyclamate resulted in a significant decrease in cell viability. Alizarin red staining experiment revealed that sodium cyclamate decreased the mineralization capacity of osteoblasts. The present results suggest that sodium cyclamate can seriously inhibit osteoblast proliferation and differentiation (1).
In this study results indicate that sodium cyclamate can not only bind to the minor groove of DNA, but also intercalate in DNA base pairs. The binding value for DNA saturation estimated to be 1.67 based on RLS data also indicated that sodium cyclamate may cause DNA damage (2).
(1) Chen Z, Chen G, Zhou K, Zhang P, Ren X, Mei X. Toxicity of food sweetener-sodium cyclamate on osteoblasts cells. Biochem Biophys Res Commun. 2019 Jan 8;508(2):507-511. doi: 10.1016/j.bbrc.2018.11.172.
(2) Hu Y, Xie M, Wu X. Interaction studies of sodium cyclamate with DNA revealed by spectroscopy methods. Spectrochim Acta A Mol Biomol Spectrosc. 2019 Sep 5;220:117085. doi: 10.1016/j.saa.2019.04.077.
Compendium of the most significant studies with reference to properties, intake, effects.Durán Agüero S, Angarita Dávila L, Escobar Contreras MC, Rojas Gómez D, de Assis Cost ...
Compendium of the most significant studies with reference to properties, intake, effects.
Durán Agüero S, Angarita Dávila L, Escobar Contreras MC, Rojas Gómez D, de Assis Costa J. Noncaloric Sweeteners in Children: A Controversial Theme. Biomed Res Int. 2018 Jan 8;2018:4806534. doi: 10.1155/2018/4806534.
Weihrauch MR, Diehl V. Artificial sweeteners--do they bear a carcinogenic risk? Ann Oncol. 2004 Oct;15(10):1460-5. doi: 10.1093/annonc/mdh256.
Leban I, Rudan-Tasic D, Lah N, Klofutar C. Structures of artificial sweeteners--cyclamic acid and sodium cyclamate with other cyclamates. Acta Crystallogr B. 2007 Jun;63(Pt 3):418-25. doi: 10.1107/S0108768107013961.
Knowles MA, Jani H, Hicks RM. Induction of morphological changes in the urothelium of cultured adult rat bladder by sodium saccharin and sodium cyclamate. Carcinogenesis. 1986 May;7(5):767-74. doi: 10.1093/carcin/7.5.767.
Brower LP. Sodium cyclamate and bladder carcinoma. Science. 1970 Oct 30;170(3957):558. doi: 10.1126/science.170.3957.558.
Bopp BA, Sonders RC, Kesterson JW. Toxicological aspects of cyclamate and cyclohexylamine. Crit Rev Toxicol. 1986;16(3):213-306. doi: 10.3109/10408448609037465.
Renwick AG, Williams RT. The fate of cyclamate in man and other species. Biochem J. 1972 Oct;129(4):869-79. doi: 10.1042/bj1290869.
Guo W, Li J, Liu Q, Shi J, Gao Y. Tracking the fate of artificial sweeteners within the coastal waters of Shenzhen city, China: From wastewater treatment plants to sea. J Hazard Mater. 2021 Jul 15;414:125498. doi: 10.1016/j.jhazmat.2021.125498.
Nakama KA, Dos Santos RB, Serpa P, Maciel TR, Haas SE. Organoleptic excipients used in pediatric antibiotics. Arch Pediatr. 2019 Oct;26(7):431-436. doi: 10.1016/j.arcped.2019.09.008.
Behrens M, Blank K, Meyerhof W. Blends of Non-caloric Sweeteners Saccharin and Cyclamate Show Reduced Off-Taste due to TAS2R Bitter Receptor Inhibition. Cell Chem Biol. 2017 Oct 19;24(10):1199-1204.e2. doi: 10.1016/j.chembiol.2017.08.004.
Sodium cyclamate 
