Compendium of the most significant studies with reference to properties, intake, effects.

Agyare C, Spiegler V, Asase A, Scholz M, Hempel G, Hensel A. An ethnopharmacological survey of medicinal plants traditionally used for cancer treatment in the Ashanti region, Ghana. J Ethnopharmacol. 2018 Feb 15;212:137-152. doi: 10.1016/j.jep.2017.10.019.

Abstract. The aim of the following study is the identification of medicinal plants used for cancer treatment by the traditional healers in the Ashanti area of Ghana and to cross-reference the identified plant species with published scientific literature.

AlQathama A, Ezuruike UF, Mazzari ALDA, Yonbawi A, Chieli E, Prieto JM. Effects of Selected Nigerian Medicinal Plants on the Viability, Mobility, and Multidrug-Resistant Mechanisms in Liver, Colon, and Skin Cancer Cell Lines. Front Pharmacol. 2020 Sep 15;11:546439. doi: 10.3389/fphar.2020.546439.

Abstract.  We selected 27 popular herbal infusions widely used in Nigeria for diabetes and studied their effects on a panel of liver (HepG2), colon (Caco2), and skin (B16-F10) cancer cells. 

Zhou MM, Zhang WY, Li RJ, Guo C, Wei SS, Tian XM, Luo J, Kong LY. Anti-inflammatory activity of Khayandirobilide A from Khaya senegalensis via NF-κB, AP-1 and p38 MAPK/Nrf2/HO-1 signaling pathways in lipopolysaccharide-stimulated RAW 264.7 and BV-2 cells. Phytomedicine. 2018 Mar 15;42:152-163. doi: 10.1016/j.phymed.2018.03.016.

Abstract. The objective of this study is to evaluate the anti-inflammatory activity of Khayandirobilide A (KLA), a new andirobin-type limonoid with modified furan ring isolated from the Khaya senegalensis (Desr.) A. Juss., and to explore its potential underlying mechanisms in LPS-stimulated inflammatory models.

Olugbami JO, Damoiseaux R, Odunola OA, Gimzewski JK. Mitigation of aflatoxin B1- and sodium arsenite-induced cytotoxicities in HUC-PC urinary bladder cells by curcumin and Khaya senegalensis. J Basic Clin Physiol Pharmacol. 2020 Apr 22;31(4):/j/jbcpp.2020.31.issue-4/jbcpp-2019-0309/jbcpp-2019-0309.xml. doi: 10.1515/jbcpp-2019-0309.

Abstract. We investigated the possible cytotoxic bio-interactions between AFB1 and sodium arsenite (SA) in urinary bladder cells. We also assessed the cytoprotective effects of curcumin and the ethanol stem bark extract of Khaya senegalensis (K2S).

Oyebanji VO, Emikpe BO, Oladele OA, Osowole OI, Salaam A, Odeniyi MA, Kasali O, Akinboade OA. Clinicopathological evaluation of Newcastle disease virus vaccination using gums from Cedrela odorata and Khaya senegalensis as delivery agents in challenged chickens. Int J Vet Sci Med. 2017 Nov 9;5(2):135-142. doi: 10.1016/j.ijvsm.2017.09.002.

Abstract. Following previous studies on delivery potential and immune response of chickens given Newcastle disease vaccine with gums, this study was conducted to evaluate the protective ability of vaccines delivered with plant gums against clinicopathological features of Newcastle disease (ND).

Ibrahim MA, Koorbanally NA, Islam MS. Antioxidative activity and inhibition of key enzymes linked to type-2 diabetes (α-glucosidase and α-amylase) by Khaya senegalensis. Acta Pharm. 2014 Sep;64(3):311-24. doi: 10.2478/acph-2014-0025.

Abstract.  This study evaluated the in vitro antioxidative activity of Khaya senegalensis extracts and inhibitory effects of some solvent fractions on α-glucosidase and α-amylase activities. The stem bark, root and leaf samples of the plant were sequentially extracted with ethyl acetate, ethanol and water and then tested for antioxidative activity.

Khaya senegalensis (A.Juss) is an evergreen tree that belongs to the Meliaceae family and is better known as African Mahogany. It is 1 metre in diameter and can reach a height of about 30 metres.

What it is used for and where

Medical

In traditional medicine, the pulverised bark was used as a remedy against fever, syphilis and to facilitate digestive processes.

Industrially, in our day, Khaya senegalensis is mainly used to produce gum and extracts from its bark for pharmaceutical and industrial uses.

The gum is used as a sustained-release agent in medicinal tablets and its seeds have demonstrated, isolated and studied in vitro, antimicrobial activity against Gram-negative bacteria (1). As a whole, this tree has a considerable flavonoid and phenolic acid content, but the quality of the extract, with regard to its demonstrated antioxidant activity, depends closely on the extraction methods (2).

Cosmetics

Khaya senegalensis extract was included in the formula as a preservative. In 2016, a study was submitted in France in support of a patent (3) for the cosmetic use of an extract of Khaya senegalensis to maintain or increase collagen expression and other skin benefits.

Khaya senegalensis studies

References________________________________________________________________________

(1) Jiang YH, Jiang TJ, Lv XF, Yu XF, Chi WQ. Antimicrobial mexicanolide limonoids from the seeds of Khaya senegalensis. J Asian Nat Prod Res. 2021 Sep 28:1-7. doi: 10.1080/10286020.2021.1972981.

(2) de la Luz Cádiz-Gurrea M, Sinan KI, Zengin G, Bene K, Etienne OK, Leyva-Jiménez FJ, Fernández-Ochoa Á, Del Carmen Villegas-Aguilar M, Mahomoodally MF, Lobine D, Ferrante C, Segura-Carretero A. Bioactivity assays, chemical characterization, ADMET predictions and network analysis of Khaya senegalensis A. Juss (Meliaceae) extracts. Food Res Int. 2021 Jan;139:109970. doi: 10.1016/j.foodres.2020.109970. 

(3) https://patentimages.storage.googleapis.com/f7/ce/d2/80bb990d4cab27/FR3049859A1.pdf