Compendium of the most significant studies with reference to properties, intake, effects.

Lomelí-Rodríguez, M., Corpas-Martínez, J. R., Willis, S., Mulholland, R., & Lopez-Sanchez, J. A. (2018). Synthesis and characterization of renewable polyester coil coatings from biomass-derived isosorbide, FDCA, 1, 5-pentanediol, succinic acid, and 1, 3-propanediol. Polymers, 10(6), 600.

Abstract. This research study provides a range of fully bio-derived polyester coil coatings with tunable properties of industrial interest, highlighting the importance of renewable polymers towards a successful bioeconomy

Busch, R., Graubaum, H. J., Gruenwald, J., & Faergemann, J. (2009). Therapeutic effect of 1, 5-pentanediol for herpes simplex labialis: A randomized, double-blind, placebo-controlled clinical trial. Advances in therapy, 26(7), 719-727.

Abstract.  The objective of the present study was to examine the prophylactic and therapeutic efficacy of 1,5-pentanediol (PD) gel in patients with recurrent episodes of herpes labialis.

Brentzel, Z. J., Barnett, K. J., Huang, K., Maravelias, C. T., Dumesic, J. A., & Huber, G. W. (2017). Chemicals from biomass: Combining ring‐opening tautomerization and hydrogenation reactions to produce 1, 5‐pentanediol from furfural. ChemSusChem, 10(7), 1351-1355.

Abstract. A process for the synthesis of 1,5-pentanediol (1,5-PD) with 84 % yield from furfural is developed, utilizing dehydration/hydration, ring-opening tautomerization, and hydrogenation reactions.

Nakagawa, Y., & Tomishige, K. (2012). Production of 1, 5-pentanediol from biomass via furfural and tetrahydrofurfuryl alcohol. Catalysis today, 195(1), 136-143.

Abstract. Production of 1,5-pentanediol from tetrahydrofurfuryl alcohol, which can be produced from biomass via furfural, is reviewed. 

Koso, S., Ueda, N., Shinmi, Y., Okumura, K., Kizuka, T., & Tomishige, K. (2009). Promoting effect of Mo on the hydrogenolysis of tetrahydrofurfuryl alcohol to 1, 5-pentanediol over Rh/SiO2. Journal of Catalysis, 267(1), 89-92.

Abstract. Furanic compounds are promising intermediates in the production of non-petroleum-derived chemicals because other biomass-related raw materials usually have a much higher oxygen content.

Koso, S., Furikado, I., Shimao, A., Miyazawa, T., Kunimori, K., & Tomishige, K. (2009). Chemoselective hydrogenolysis of tetrahydrofurfuryl alcohol to 1, 5-pentanediol. Chemical communications, (15), 2035-2037.

Abstract. Direct conversion of tetrahydrofurfuryl alcohol, which is one of the biomass-derived chemicals, to 1,5-pentanediol was realized by chemoselective hydrogenolysis catalyzed by Rh/SiO2 modified with ReOx species, and this reaction route gave higher yield than the conventional multi-step method.

Gnanamani, M. K., Martinelli, M., Badoga, S., Hopps, S. D., & Davis, B. H. (2018). Dehydration of 1, 5‐Pentanediol over CeO2‐MeOx Catalysts. ChemCatChem, 10(20), 4629-4635.

Abstract. The defect sites on CeO2 catalyze both dehydration and cyclization reactions for 1,5-pentanediol.

Al-Yusufi, M., Steinfeldt, N., Eckelt, R., Atia, H., Lund, H., Bartling, S., ... & Köckritz, A. (2022). Efficient Base Nickel-Catalyzed Hydrogenolysis of Furfural-Derived Tetrahydrofurfuryl Alcohol to 1, 5-Pentanediol. ACS Sustainable Chemistry & Engineering.

Abstract.  The highest yield of 1,5-PeD was 88% in a batch system and 73% in a flow system using 40Ni-La reduced.

1,5-pentanediol is a chemical compound, primary alcohol obtained industrially from tetrahydrofurfuryl alcohol by various catalytic methods including purification and isolation of the intermediates to obtain a yield of 70%.

It occurs as an oily clear liquid that is miscible with water, methanol, ethanol, ketones and ethyl acetate. pH 7.5

What it is used for and where

Cosmetics

Intermediate for personal care products as a fragrance and moisturising agent.

Other uses

1,5-pentanediol can be used as a monomer for the production of polyesters and chain extender in polyurethanes, as a polymerisation additive (plasticiser), to produce polycarbonate diols.  Chemical solvent. Synthesis of propiconazole from pesticides.

For more information:      1,5-pentanediol studies

Typical commercial product characteristics 1,5-Pentanediol

Appearance	Colorless transparent liquid
Boiling Point	239.0±0.0°C at 760 mmHg
Melting Point	-18°C
Flash Point	129.4±0.0°C
Density	1.0±0.1 g/cm3      0.994 g/mL at 25°C (lit.)
Acid Value	0.1 max (mg KOH/g)
Moisture	0.1% max
Water	≤1.0%
Sulphated ash	≤0.5%/1g
Heavy metals	≤10 ppm
Residue on ignition	≤0.1%
Total Impurities	0.5%
PSA	40.46000
LogP	-0.60
Vapor Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.446
Safety

• Molecular Formula  C₅H₁₂O₂
• Linear Formula   HO(CH₂₎₅OH
• Molecular Weight  104.15  
• Exact Mass   104.083733
• CAS  111-29-5
• UNII    07UXZ0SCST
• EC Number   203-854-4
• DSSTox Substance ID  DTXSID2041256
• IUPAC  pentane-1,5-diol
• InChI=1S/C5H12O2/c6-4-2-1-3-5-7/h6-7H,1-5H2  
• InChl Key     ALQSHHUCVQOPAS-UHFFFAOYSA-N 
• SMILES   C(CCO)CCO
• MDL number  MFCD00002978
• PubChem Substance ID    329767415
• ChEBI  185431
• Beilstein   1560130
• NACRES  NA.22
• NSC   5927
• RTECS   SA0480000

Synonyms

• pentane-1,5-diol
• 1,5-Dihydroxypentane
• Pentamethylene glycol
• 1,5-Pentylene glycol
• 1,5 Pentanediol
• 1,5-Pentamethylene glycol