Compendium of the most significant studies with reference to properties, intake, effects.

Huth S, Huth L, Marquardt Y, Cheremkhina M, Heise R, Baron JM. MMP-3 plays a major role in calcium pantothenate-promoted wound healing after fractional ablative laser treatment. Lasers Med Sci. 2022 Mar;37(2):887-894. doi: 10.1007/s10103-021-03328-8. 

Abstract. Ablative fractional laser treatment leads to a loss of matrix metalloproteinase-3 (MMP-3) expression; therefore, in the present in vitro study, we addressed the role of MMP-3 and its regulation by calcium pantothenate in wound healing processes at the molecular level. Utilizing confocal laser microscopy, we investigated MMP-3 protein expression in fractional ablative CO2 laser-irradiated skin models. 

Schmitt L, Huth S, Amann PM, Marquardt Y, Heise R, Fietkau K, Huth L, Steiner T, Hölzle F, Baron JM. Direct biological effects of fractional ultrapulsed CO2 laser irradiation on keratinocytes and fibroblasts in human organotypic full-thickness 3D skin models. Lasers Med Sci. 2018 May;33(4):765-772. doi: 10.1007/s10103-017-2409-1.

Abstract. Molecular effects of various ablative and non-ablative laser treatments on human skin cells-especially primary effects on epidermal keratinocytes and dermal fibroblasts-are not yet fully understood. We present the first study addressing molecular effects of fractional non-sequential ultrapulsed CO2 laser treatment using a 3D skin model that allows standardized investigations of time-dependent molecular changes ex vivo. 

Weimann BI, Hermann D. Studies on wound healing: effects of calcium D-pantothenate on the migration, proliferation and protein synthesis of human dermal fibroblasts in culture. Int J Vitam Nutr Res. 1999 Mar;69(2):113-9. doi: 10.1024/0300-9831.69.2.113.

Abstract. The effect of calcium D-pantothenate on the migration, proliferation and protein synthesis of human dermal fibroblasts from three different donors was investigated. The migration of cells into a wounded area was dose-dependently stimulated by Ca D-pantothenate. The number of cells that migrated across the edge of the wound increased from 32 +/- 7 cells/mm without Ca D-pantothenate to 76 +/- 2 cells/mm with 100 mg/ml Ca D-pantothenate. 

Brzezińska-Wcisło L. Ocena skuteczności witaminy B6 i pantotenianu wapniowego na wzrost włosów w aspekcie klinicznym i trichologicznym w łysieniu rozlanym kobiet  Evaluation of vitamin B6 and calcium pantothenate effectiveness on hair growth from clinical and trichographic aspects for treatment of diffuse alopecia in women. Wiad Lek. 2001;54(1-2):11-8.

Abstract. The aim of the study was the clinical and trichological examination (trichogram and hair loss evaluation) conducted comparatively before and after the treatment in 46 women between pubescence and 30 years of age who had symptoms of diffuse alopecia. Calcium pantothenate was administered twice a day orally in doses 100 mg for 4-5 months.

Calcium pantothenate  is a chemical compound, calcium salt of vitamin B5 or pantothenic acid, found everywhere in plants and animal tissue.

It appears as a white hygroscopic powder with a bitter taste.  Easily soluble in water, slightly soluble in ethanol. The aqueous solution is slightly alkaline.

What it is used for and where

General biochemical reagent

Medical

Widely used in clinical practice for wound healing, it stimulates epithelial cell growth. A positive effect of Calcium pantothenate on the migration and proliferation of fibroblasts in culture as well as a stimulating effect on the proliferation of dermal fibroblasts has been established (1).

Cosmetics

Moisturising agent, in hair products prevents split ends, increases hair volume and shine.

Hair conditioning agent. A significant number of ingredients with specific and targeted purposes may co-exist in hair shampoo formulations: cleansers, conditioners, thickeners, matting agents, sequestering agents, fragrances, preservatives, special additives. However, the indispensable ingredients are the cleansers and conditioners as they are necessary and sufficient for hair cleansing and manageability. The others act as commercial and non-essential auxiliaries such as: appearance, fragrance, colouring, etc. Hair conditioning agents have the task of increasing shine, manageability and volume, and reducing static electricity, especially after treatments such as colouring, ironing, waving, drying and brushing. They are, in practice, dispersants that may contain cationic surfactants, thickeners, emollients, polymers. The typology of hair conditioning agents includes: intensive conditioners, instant conditioners, thickening conditioners, drying conditioners. They can perform their task generally accompanied by other different ingredients.

Skin conditioning agent - Miscellaneous.  This ingredient has the task of modifying and improving the condition of the skin when it is damaged or dry, reducing flaking and restoring its elasticity.

Food

As a food supplement it promotes the metabolism of carbohydrates and fats, the body's own proteins.

The most relevant studies on this chemical compound have been selected with a summary of their contents:

Calcium pantothenate studies

Typical commercial product characteristics Calcium pantothenate

• Molecular Formula  C₁₈H₃₂CaN₂O₁₀
• Linear Formula    HOCH₂C(CH₃)₂CH(OH)CONHCH₂CH₂CO₂ ·1/2Ca
• Molecular Weight     238.27
• CAS  137-08-6
• UNII    568ET80C3D
• EC Number   205-278-9
• DSSTox Substance ID  DTXSID8040438
• IUPAC  calcium;3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoate
• InChI=1S/2C9H17NO5.Ca/c2*1-9(2,5-11)7(14)8(15)10-4-3-6(12)13;/h2*7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13);/q;;+2/p-2/t2*7-;/m00./s1 
• InChl Key      FAPWYRCQGJNNSJ-UBKPKTQASA-L
• SMILES   CC(C)(CO)C(C(=O)NCCC(=O)[O-])O.CC(C)(CO)C(C(=O)NCCC(=O)[O-])O.[Ca+2]
• MDL number  MFCD00002766
• PubChem Substance ID    24893098
• ChEBI  31345
• Beilstein    3769272
• eCl@ss    34058012
• NACRES NA.21
• RXCUI  1918    
• RTECS   RU4375000
• NCI   C74545

Synonyms

• Calcium D-pantothenate
• D-panthenol
• calcium;3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoate
• (R)-(+)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine hemicalcium salt
• Pantholin

References_____________________________________________________________________

(1) Wiederholt T, Heise R, Skazik C, Marquardt Y, Joussen S, Erdmann K, Schröder H, Merk HF, Baron JM. Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x.