Compendium of the most significant studies with reference to properties, intake, effects.

Hlaoperm C, Choowongkomon K, Pruksakorn C, Rattanasrisomporn J. Development of an easy-to-use urease kit for detecting Helicobacter pylori in canine gastric mucosa. Vet World. 2021 Jul;14(7):1977-1987. doi: 10.14202/vetworld.2021.

Abstract. Helicobacter pylori is an important pathogen in humans and animals involved in chronic gastritis, leading to the development of gastric cancer. Urease produced by H. pylori is an enzyme that promotes bacterial colonization and can be used clinically as a biomarker of H. pylori infection as part of a rapid urease test (RUT). A test with high specificity (95-100%) would be more convenient and faster than histopathology, bacterial culture, and polymerase chain reaction (PCR). The aim of this study was to develop a simple, cheap, and fast kit for detecting H. pylori infection in the gastric mucosa of canines, which can be used in clinical practice for diagnosing infection with this bacterium.

Kim DH, Lee KC, Han SY. Cyclosporin A Aggravates Calcification of Vascular Smooth Muscle Cells Under High-Glucose Conditions with a Calcifying Medium. Ann Transplant. 2018 Feb 13;23:112-118. doi: 10.12659/aot.908168.

Abstract. Vascular calcification (VC) progresses substantially even after kidney transplantation, and is a predictor of morbidity and mortality. However, the effect of cyclosporin A (CsA) on VC has not been reported in diabetic kidney transplant patients. In this study, we evaluated the effect of CsA on the VC of mouse vascular smooth muscle cells (VSMCs) under high glucose (HG)....Calcification was observed 14 days after exposure to a calcifying medium (sodium phosphate monobasic and dibasic mixture).

Aliabadi HM, Romanick M, Desai S, Lavasanifar A. Effect of buffer and antioxidant on stability of a mercaptopurine suspension. Am J Health Syst Pharm. 2008 Mar 1;65(5):441-7. doi: 10.2146/ajhp070325. 

Abstract. Three additional formulations were prepared by adding an antioxidant (ascorbic acid 10 mg), a buffer (sodium phosphate monobasic monohydrate 500 mg), and a combination of antioxidant and buffer to the reference formulation. ...

Idink, M. J., & Grünberg, W. (2015). Enteral administration of monosodium phosphate, monopotassium phosphate and monocalcium phosphate for the treatment of hypophosphataemia in lactating dairy cattle. Veterinary Record, 176(19), 494-494.

Abstract.  Objectives of this study were to compare the efficacy of monopotassium phosphate (KH2 PO4) and monocalcium phosphate (Ca(H2 PO4)2) to monosodium phosphate (NaH2 PO4) in P-depleted cows.

Ewoti, O. V. N., Nola, M., Moungang, L. M., Nougang, M. E., Krier, F., & Chihib, N. E. (2011). Adhesion of Escherichia coli and" Pseudomonas aeruginosa" on Rock Surface in Aquatic Microcosm: Assessment of the Influence of Dissolved Magnesium Sulfate and Monosodium Phosphate. Research Journal of Environmental and Earth Sciences, 3(4), 364-374.

Abstract. This study aims at assessing the aquatic microcosm conditions, the influence of MgSO_4 and NaH_2PO_4 on the adhesion of ＂P. aeruginosa＂ and ＂E. coli＂ on the basalt, micaschist, granite and sandstone fragments during 180 to 1440 min. Results showed that in the presence of MgSO_4 at concentrations of 0.02, 0.04, 0.06 and 0.08 mol/L the abundances of ＂P. aeruginosa＂...

Mendoza, J., Legido, J., Rubio, S., & Gisbert, J. P. (2007). Systematic review: the adverse effects of sodium phosphate enema. Alimentary pharmacology & therapeutics, 26(1), 9-20.

Abstract. A systematic review of the literature was conducted to identify the most common adverse effects of sodium-phosphate enemas and associated risk factors...

Sodium phosphate monobasic or Monobasic sodium phosphate is a chemical compound obtained from the reaction of phosphoric acid with sodium sources.

It appears as a white crystalline powder soluble in water and acid water, insoluble in ethanol. 

What it is used for and where

Human nutrition

Monobasic sodium phosphate is commonly used for oral phosphorous supplementation.

In the food and fermentation industry it functions as a buffering agent, a raw material in yeast powder, an adhesive and curing agent for bread and condiments. Improves appearance and quality as an acid agent in evaporated milk. Stabilising agent in cheese and other dairy products, meat, stabiliser in fish products, binder, buffer in yeast.

As a leavening agent it controls the speed of product fermentation, reduces rehydration time and prevents stickiness.

In the production of baked goods, cracker cakes can reduce fermentation time, extend shelf life.

Animal nutrition

Sodium phosphate monobasic is commonly used for oral phosphorous supplementation.

In animal feed production, it is used as a source of phosphorous for fish and shrimp feed, as its solubility in water allows phosphorous to be fully utilised by aquatic fish and shrimp, reducing the cost of aquaculture and water pollution caused by phosphorous loss in the aquaculture process, thus meeting environmental protection requirements.

Medical

Together with dibasic sodium phosphate, it is used in adults and children in evacuative solutions such as disposable enemas for the treatment of constipation, the treatment of acute and chronic constipation and also for colon cleansing as preparation for surgical procedures (1). These chemical compounds increase the water content and volume of stools, creating a rectal distention effect. The required effect is usually produced within about 5 minutes.

Other uses

Used in the manufacture of household detergents, metal cleaners, colour additives and pigment precipitators.

Adjuvant in boiler water treatment by electroplating (covering non-precious metals with a light layer of precious metal).

Acidity buffer, excipient in mica processing.

Raw material for the production of sodium hexametaphosphate and polypolyphosphate.

Safety

EFSA's Scientific Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids issued a safety assessment of monosodium phosphate considering it safe when used for long-term storage and/or hot-filling up to 95 °C (2).

Sodium phosphate monobasic studies

Typical commercial product characteristics MonoSodium Phosphate

Appearance	White crystal or crystalline powder
pH	4.1-4.7
Boiling Point	100°C
Melting Point	<0ºC
Density	1.40 g/mL at 20°C
PSA	90.40000
Water Insoluble	≤0.2%
Loss on Drying	≤2.0%
Phosphorous	25.3~26.6
As	≤0.001%
Lead	≤0.003%
Fluoride	≤0.02%
Sulphates	≤2.0%
Chromium	≤0.003%
Safety

Price

100g    €31.50

1kg      €104.00

• Molecular Formula NaH₂PO₄     H₂NaO₄P    
• PMolecular Weight    119.977
• Exact Mass    119.958839
• CAS  7558-80-7
• UNII    KH7I04HPUU
• EC Number   231-449-2    231-558-5
• DSSTox Substance ID  DTXSID7035222
• IUPAC  sodium;dihydrogen phosphate
• InChI=1S/Na.H3O4P/c;1-5(2,3)4/h;(H3,1,2,3,4)/q+1;/p-1 
• InChl Key      AJPJDKMHJJGVTQ-UHFFFAOYSA-M
• SMILES   OP(=O)(O)[O-].[Na+]
• MDL number  MFCD00003527
• PubChem Substance ID    24899443
• ChEBI  37585
• RXCUI        349753
• eCl@ss       38070208
• RTECS   WA1900000

Synonyms

• sodium dihydrogenphosphate
• Sodium dihydrogen (16O4)phosphate
• Sodium dihydrogenorthophosphate

References_____________________________________________________________________

(1) Osgard E, Jackson JL, Strong J. A randomized trial comparing three methods of bowel preparation for flexible sigmoidoscopy. Am J Gastroenterol. 1998 Jul;93(7):1126-30. doi: 10.1111/j.1572-0241.1998.00342.x. 

(2) EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF). (2013). Scientific Opinion on the safety evaluation of the active substances, iron, polyethyleneglycol, disodium pyrophosphate, monosodium phosphate and sodium chloride for use in food contact materials. EFSA Journal, 11(6), 3245.