Compendium of the most significant studies with reference to properties, intake, effects.
Montenegro L, Carbone C, Paolino D, Drago R, Stancampiano AH, Puglisi G. In vitro skin permeation of sunscreen agents from O/W emulsions. Int J Cosmet Sci. 2008 Feb;30(1):57-65. doi: 10.1111/j.1468-2494.2008.00417.x.
Abstract. The effects of different emulsifiers on the in vitro permeation through human skin of two sunscreen agents [octylmethoxycinnamate (OMC) and butylmethoxydibenzoylmethane (BMBM)] were investigated from O/W emulsions. The test formulations were prepared using the same oil and aqueous phase ingredients and the following emulsifier and coemulsifier systems: Emulgade SE((R)) (ceteareth-12 and ceteareth-20 and cetearyl alcohol and cetyl palmitate) and glycerylmonostearate (emulsion 1); Brij 72((R)) (steareth-2), Brij 721((R)) (steareth-21) and cetearyl alcohol (emulsion 2); Phytocream((R)) (potassium palmitoyl-hydrolysed wheat protein and glyceryl stearate and cetearyl alcohol) and glycerylmonostearate (emulsion 3); Montanov 68((R)) (cetearyl glucoside and cetearyl alcohol) (emulsion 4); Xalifin-15((R)) (C(15-20) acid PEG-8 ester) and cetearyl alcohol (emulsion 5). The cumulative amount of OMC that permeated in vitro through human skin after 22 h from the formulations being tested decreased in the order 3 > 1 congruent with 4 > 5 > 2 and was about nine-fold higher from emulsion 3 compared with that from emulsion 2. As regards BMBM, no significant difference was observed as regards its skin permeation from emulsions 1, 3, 4 and 5, whereas formulation 2 allowed significantly lower amounts of BMBM to permeate the skin. In vitro release experiments of OMC and BMBM from emulsions 1-6 through cellulose acetate membranes showed that only emulsions 4 and 5 provided pseudo-first-order release rates only for OMC. The results of this study suggest that the type of emulsifying systems used to prepare an O/W emulsion may strongly affect sunscreen skin permeation from these formulations. Therefore, the vehicle effects should be carefully considered in the formulation of sunscreen products.
Śliwa K, Śliwa P. The Accumulated Effect of the Number of Ethylene Oxide Units and/or Carbon Chain Length in Surfactants Structure on the Nano-Micellar Extraction of Flavonoids. J Funct Biomater. 2020 Aug 7;11(3):57. doi: 10.3390/jfb11030057.
Abstract. Classical extraction methods used for isolation of active substances from plant material are expensive, complicated and often environmentally unfriendly. The ultrasonic assistance micelle-mediated extraction method (UAMME), based on green chemistry principles, seems to be an interesting alternative. This work aimed to find a connection between the chemical structure of non-ionic surfactants and the efficiency of the extraction process. The effect of hydrophobic chain length and number of ethoxy groups on the quality of Bidens tripartite extracts was investigated. Several ethoxylated fatty alcohols were used: Ceteareth-20, Steareth-20, Oleth-20, Oleth-10, Oleth-5, C12-C13 Pareth-12, C12-C15 Pareth-12 and Ceteareth-12. The bioflavonoid compositions with the HPLC method was determined. The hydrophilic lipophilic balance (HLB) of studied surfactants, as well as the surface tension of surfactant solutions, were compared, to determine the explanation for the obtained differences in bioflavonoids concentration. The structural changes influenced by polyphenol extraction were monitored using Dynamic Light Scattering (DLS) measurements. In this work, probably for the first time, the connection between the chemical structure of non-ionic surfactants and the efficiency of the extraction process was found. The experimental and theoretical approach rationalized the choice of an appropriate eluent. We propose some structurally dependent factors, whose optimal value gave a high efficiency to the UAMME.
Zanatta CF, de Faria Sato AM, de Camargo FB Jr, Campos PM, Rocha-Filho PA. Rheological behavior, zeta potential, and accelerated stability tests of Buriti oil (Mauritia flexuosa) emulsions containing lyotropic liquid crystals. Drug Dev Ind Pharm. 2010 Jan;36(1):93-101. doi: 10.3109/03639040903099728.
Abstract. Background: It is well known that the Amazon region presents a huge biodiversity; therefore, countless natural resources are being employed in the production of phytocosmetics and phytomedicines. Objective: The purpose of this work was to obtain emulsions produced with Buriti oil and non-ionic surfactants. Methods: Two surfactant systems were employed (Steareth-2 associated to Ceteareth-5 and to Ceteareth-20) to produce the emulsions using phase diagram method. Emulsions were obtained by echo-planar imaging method at 75°C. Rheological behavior and zeta potential were evaluated, and accelerated stability tests were performed. Results: All emulsions analyzed presented pseudoplastic behavior. Zeta potential values were obtained between -14.2 and -53.3 mV. The formulations did not show changes in either physical stability, pH, or rheological behavior after accelerated stability tests. Significant differences were observed only after temperature cycling test. Conclusion: Based on these results, the emulsions obtained could be considered as promising delivery systems.
Pena, L. E., & Lee, B. L. (1993). Consistency development and destabilization of. J. Soc. Cosmet. Chem, 44, 337-345.
Abstract. Emulsions are thermodynamically unstable and with time show progressive signs of this instability with eventual phase separation. Itis also an established fact that creams based on nonionic emulsifier systems exhibit an initial period of delayed consistency development prior to the destabilization process. To illustrate these phenomena, a cream having a nonionic emulsifier system is destabilized by a surface-active ingredienthat also exaggerates the period of retarded consistency development. Using rheologic and microscopic techniques, this study presents asystematic approach by which consistency development and destabilization can be monitored. Characteristic patterns in the rheograms upon aging are correlated with changes seen microscopically, and specifichanges signaling the beginning of the destabilization process are identified. Rheologically, destabilization becomes apparent through formation of additional spurs and inflections at low shear rates, a decrease in hysteresis, and a shift to lower maximum shear stress values. Microscopically, polarized light shows formation of diffuse, weakly birefringent structures while ordinary light shows an increase in droplet size. Thermal optical videomicroscopy and trace substance analysis have identified the structures as segments of agglomerated oil phase and verify the photomicroscopy observation that the oil and wax components phase separate as distinct entities.
Schmidts, T., Dobler, D., Nissing, C., & Runkel, F. (2009). Influence of hydrophilic surfactants on the properties of multiple W/O/W emulsions. Journal of colloid and interface science, 338(1), 184-192.
Abstract. Multiple W/O/W emulsions for topical application using Span 80 as a lipophilic emulsifier were prepared. Several hydrophilic emulsifiers were tested in respect of their suitability for the preparation of multiple emulsions. In addition, the effect of different oil-phase compositions on emulsion stability was investigated. The physicochemical parameters of the formulations were characterized and their long-term stability was evaluated by means of rheological measurements, droplet size observations and conductivity analysis. As discovered, the modification of an oil-phase composition results in a decrease in the diffusion coefficient of water and water-soluble substances and, consequently, in enhanced stability. The influence of the release of electrolytes from the inner to the outer water phase on the emulsion stability behaviour was investigated. It was found, that the effect of the hydrophilic emulsifiers on the formulation properties is related not only to its HLB value, but rather to its chemical composition. As a result, polyethoxylated ethers of fatty alcohols (C = 16–18) with HLBs between 15.3 and 16.2 appear to be the most suitable ones for creating stable formulations.
Ceteareth-20 
Hydride
