Compendium of the most significant studies with reference to properties, intake, effects.

Burnett, C. L., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... & Andersen, F. A. (2017). Safety assessment of amino acid alkyl amides as used in cosmetics. International journal of toxicology, 36(1_suppl), 17S-56S.

Abstract. The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the product use, formulation, and safety data of 115 amino acid alkyl amides, which function as skin and hair conditioning agents and as surfactants—cleansing agents in personal care products. Safety test data on dermal irritation and sensitization for the ingredients with the highest use concentrations, lauroyl lysine and sodium lauroyl glutamate, were reviewed and determined to adequately support the safe use of the ingredients in this report. The Panel concluded that amino acid alkyl amides are safe in the present practices of use and concentration in cosmetics, when formulated to be nonirritating.

BIGOTTI, C., GUALA, F., MERLO, E., & VILLA, G. Physiological cleansing for problematic skin.

Disodium capryloyl glutamate is a chemical compound, the disodium salt of the amide formed from the reaction of capryloyl chloride and glutamic acid in a basic environment. (produced via the Schotten-Baumann reaction).

It appears as a colourless to light yellow liquid.

What it is used for and where

Cosmetics

Surfactant cleaning agent with good cleaning power, fragrance. Not too aggressive on the skin.

Safety

May contain: caprylic acid, propylene glycol, disodium glutamate, sodium chloride. It is considered non-toxic, non-mutagenic, non-irritating to skin and eyes, non-sensitising.

The most relevant studies on this ingredient have been selected with a summary of their contents:

Disodium capryloyl glutamate studies

• Molecular Formula      C₁₃H₂₁NNa₂O₅         C₁₃H₂₁NO₅.₂Na
• PMolecular Weight     317.29
• Exact Mass     317.12200
• CAS  167888-81-5    91697-07-3
• UNII    MCG3T4GPL4
• EC Number   605-493-1
• DSSTox Substance ID  DTXSID50168422
• IUPAC  disodium;(2S)-2-(octanoylamino)pentanedioate
• InChl=1S/C13H23NO5.2Na/c1-2-3-4-5-6-7-11(15)14-10(13(18)19)8-9-12(16)17;;/h10H,2-9H2,1H3,(H,14,15)(H,16,17)(H,18,19);;/q;2*+1/p-2/t10-;;/m0../s1
• InChl Key      JRHWWJSWHFFZRY-XRIOVQLTSA-L
• SMILES  CCCCCCCC(=O)NC(CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]
• MDL number  
• PubChem Substance ID    71587566

Synonyms:

• Emulvama AGW
• L-Glutamic acid,N-(1-oxooctyl)-,disodium salt
• Protelan AG 8
• L-Glutamic acid,N-(1-oxooctyl)-,sodium salt (1:2)