Characteristics in Non-Vitamin K Antagonist Oral Anticoagulant-Related Intracerebral Hemorrhage.
Gerner ST, Kuramatsu JB, Sembill JA, Sprügel MI, Hagen M, Knappe RU, Endres M, Haeusler KG, Sobesky J, Schurig J, Zweynert S, Bauer M, Vajkoczy P, Ringleb PA, Purrucker JC, Rizos T, Volkmann J, Müllges W, Kraft P, Schubert AL, Erbguth F, Nueckel M, Schellinger PD, Glahn J, Knappe UJ, Fink GR, Dohmen C, Stetefeld H, Fisse AL, Minnerup J, Hagemann G, Rakers F, Reichmann H, Schneider H, Rahmig J, Ludolph AC, Stösser S, Neugebauer H, Röther J, Michels P, Schwarz M, Reimann G, Bäzner H, Schwert H, Claßen J, Michalski D, Grau A, Palm F, Urbanek C, Wöhrle JC, Alshammari F, Horn M, Bahner D, Witte OW, Günther A, Hamann GF, Engelhorn T, Lücking H, Dörfler A, Schwab S, Huttner HB.
Stroke. 2019 May 16:STROKEAHA118023492. doi: 10.1161/STROKEAHA.118.023492.

Effect of vitamin K on bone mineral density and fractures in adults: an updated systematic review and meta-analysis of randomised controlled trials.
Mott A, Bradley T, Wright K, Cockayne ES, Shearer MJ, Adamson J, Lanham-New SA, Torgerson DJ.
Osteoporos Int. 2019 May 10. doi: 10.1007/s00198-019-04949-0.

Increasing the dose of oral vitamin K prophylaxis and its effect on bleeding risk.
Löwensteyn YN, Jansen NJG, van Heerde M, Klein RH, Kneyber MCJ, Kuiper JW, Riedijk MA, Verlaat CWM, Visser IHE, van Waardenburg DA, van Hasselt PM.
Eur J Pediatr. 2019 May 6. doi: 10.1007/s00431-019-03391-y.

Vitamin K status and mobility limitation and disability in older adults: The Health, Aging, and Body Composition Study.
Shea MK, Kritchevsky SB, Loeser RF, Booth SL.
J Gerontol A Biol Sci Med Sci. 2019 May 6. pii: glz108. doi: 10.1093/gerona/glz108.

The Role of Vitamin K and Its Related Compounds in Mendelian and Acquired Ectopic Mineralization Disorders.
Nollet L, Van Gils M, Verschuere S, Vanakker O.
Int J Mol Sci. 2019 Apr 30;20(9). pii: E2142. doi: 10.3390/ijms20092142. Review.

The vitamin K-dependent factor, protein S, regulates brain neural stem cell migration and phagocytic activities towards glioma cells.
Ginisty A, Oliver L, Arnault P, Vallette F, Benzakour O, Coronas V.
Eur J Pharmacol. 2019 Apr 24;855:30-39. doi: 10.1016/j.ejphar.2019.04.039.

Effectiveness and Safety of Direct Oral Anticoagulants versus Vitamin K Antagonists for People Aged 75 Years and over with Atrial Fibrillation: A Systematic Review and Meta-Analyses of Observational Studies.
Mitchell A, Watson MC, Welsh T, McGrogan A.
J Clin Med. 2019 Apr 24;8(4). pii: E554. doi: 10.3390/jcm8040554. Review.

Vitamin K deficiency-induced hemorrhagic shock after thoracentesis: a case report.
Itagaki H, Hagino T.
BMC Gastroenterol. 2019 Apr 18;19(1):58. doi: 10.1186/s12876-019-0978-0.

The Relationship between Dietary Vitamin K and Depressive Symptoms in Late Adulthood: A Cross-Sectional Analysis from a Large Cohort Study.
Bolzetta F, Veronese N, Stubbs B, Noale M, Vaona A, Demurtas J, Celotto S, Cacco C, Cester A, Caruso MG, Reddavide R, Notarnicola M, Maggi S, Koyanagi A, Fornaro M, Firth J, Smith L, Solmi M.
Nutrients. 2019 Apr 5;11(4). pii: E787. doi: 10.3390/nu11040787.

CURRENT APPROACHES TO PREVENTION OF BLEEDINGS, ASSOCIATED WITH VITAMIN K DEFICIENCY IN NEWBORNS AND INFANTS.
Kiselova M.
Georgian Med News. 2019 Feb;(287):45-50

The Relationships Between Vitamin K and Cognition: A Review of Current Evidence.
Alisi L, Cao R, De Angelis C, Cafolla A, Caramia F, Cartocci G, Librando A, Fiorelli M.
Front Neurol. 2019 Mar 19;10:239. doi: 10.3389/fneur.2019.00239. eCollection 2019.

Vitamin K Dependent Proteins in Kidney Disease.
Silaghi CN, Ilyés T, Filip VP, Farcaș M, van Ballegooijen AJ, Crăciun AM.
Int J Mol Sci. 2019 Mar 29;20(7). pii: E1571. doi: 10.3390/ijms20071571. Review.

Guidelines for vitamin K prophylaxis in newborns.
Ng E, Loewy AD.
Paediatr Child Health. 2018 Sep;23(6):394-402. doi: 10.1093/pch/pxy082. Epub 2018 Aug 16.

Involvement of Vitamin K-Dependent Proteins in Vascular Calcification.
Tesfamariam B.
J Cardiovasc Pharmacol Ther. 2019 Mar 24:1074248419838501. doi: 10.1177/1074248419838501.

Vitamin K plays a fundamental role in blood clotting. Its lack would cause a wound healing.

Another important role is the regulation of kidney function.

This study presents the latest scientific evidence on vitamin K and its role in preventing age-associated diseases and/or improving the efficacy of medical treatments in ˃50-year-old mature adults (1).

It is located in:

• Vegetables, cabbage, spinach
• Fruit, bananas
• Green tea
• Cheese

Vitamin K studies

Molecular Formula: C₃₁H₄₆O₂

Molecular Weight: 450.707 g/mol

CAS: 12001-79-5  84-80-0  27696-10-2  81818-54-4

EC Number: 234-408-7  201-564-2

PubChem Substance ID 24871410

MDL number MFCD00214063

Beilstein Registry Number 2568816

Synonyms:

• Phylloquinone
• 2-Methyl-3-phytyl-1,4-naphthoquinone
• Kinadion
• 2',3'-trans-Vitamin K1
• Konakion
• Phythyl-menadion
• Mephyton
• 2-methyl-3-[(E)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione
• Monodion
• 2-Methyl-3-phytyl-1,4-naphthochinon
• Kephton
• 2-Methyl-3-phythyl-1,4-naphthochinon
• Aqua mephyton
• 3-((2E)-3,7,11,15-tetramethylhexadec-2-enyl)-2-methylnaphthalene-1,4-dione
• 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-
• 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione
• [r-[r*,R*-(E)]]-2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-napthalenedione
• 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalened- ione
• [r-[r*,R*-(E)]]-2-Methyl-3-(3-7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione
• 2-Methyl-3-[(2E)-3,7,11,15-tetramethyl-2-hexadecenyl]naphthoquinone #
• 1,4-Naphthalenedione, 2-methyl-3-((2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecenyl)-

References_______________________________________________________________________

(1) Popa DS, Bigman G, Rusu ME. The Role of Vitamin K in Humans: Implication in Aging and Age-Associated Diseases. Antioxidants (Basel). 2021 Apr 6;10(4):566. doi: 10.3390/antiox10040566.