Serotonin neuronal function from the bed to the bench: is this really a mirrored way?
Etievant A, Lau T, Lucas G, Haddjeri N.
eNeuro. 2019 May 22. pii: ENEURO.0021-19.2019. doi: 10.1523/ENEURO.0021-19.2019.

Overcoming Resistance to Selective Serotonin Reuptake Inhibitors: Targeting Serotonin, Serotonin-1A Receptors and Adult Neuroplasticity.
Vahid-Ansari F, Zhang M, Zahrai A, Albert PR.
Front Neurosci. 2019 Apr 30;13:404. doi: 10.3389/fnins.2019.00404. eCollection 2019. Review.

Lack of Brain Serotonin Affects Feeding and Differentiation of Newborn Cells in the Adult Hypothalamus.
van Lingen M, Sidorova M, Alenina N, Klempin F.
Front Cell Dev Biol. 2019 Apr 26;7:65. doi: 10.3389/fcell.2019.00065. eCollection 2019.

Serotonin receptors 2A and 1A modulate anxiety-like behavior in post-traumatic stress disordered mice.
Xiang M, Jiang Y, Hu Z, Yang Y, Du X, Botchway BO, Fang M.
Am J Transl Res. 2019 Apr 15;11(4):2288-2303. eCollection 2019.

Analysis of the Effects of Selective Serotonin (and Noradrenaline) Reuptake Inhibitors on the Risk of Dementia in Patients with Depression.
Kostev K, Bohlken J, Jacob L.
J Alzheimers Dis. 2019 May 13. doi: 10.3233/JAD-190239.

The role of general practitioners and psychiatrists in issuing initiation and follow-up prescriptions for selective serotonin (norepinephrine) reuptake inhibitors in Germany
.
Kap E, Kostev K.
Int J Clin Pharmacol Ther. 2019 May 16. doi: 10.5414/CP203410.

Relapse prevention and selective serotonin reuptake inhibitor medication in two adolescents with anorexia nervosa.
Luzier J, Rached K, Talley J.
Int J Eat Disord. 2019 May 13. doi: 10.1002/eat.23092.

The Serotonin Syndrome: From Molecular Mechanisms to Clinical Practice.
Francescangeli J, Karamchandani K, Powell M, Bonavia A.
Int J Mol Sci. 2019 May 9;20(9). pii: E2288. doi: 10.3390/ijms20092288. Review.

Serotonin Deficiency Increases Context-Dependent Fear Learning Through Modulation of Hippocampal Activity.
Waider J, Popp S, Mlinar B, Montalbano A, Bonfiglio F, Aboagye B, Thuy E, Kern R, Thiel C, Araragi N, Svirin E, Schmitt-Böhrer AG, Corradetti R, Lowry CA, Lesch KP.
Front Neurosci. 2019 Apr 24;13:245. doi: 10.3389/fnins.2019.00245. eCollection 2019.

Role of Serotonin and Dopamine in Psoriasis: A Case-Control Study.
Wardhana M, Windari M, Puspasari N, Suryawati N.
Open Access Maced J Med Sci. 2019 Apr 14;7(7):1138-1142. doi: 10.3889/oamjms.2019.267. eCollection 2019 Apr 15.

Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer's disease.
Metaxas A, Anzalone M, Vaitheeswaran R, Petersen S, Landau AM, Finsen B.
Alzheimers Res Ther. 2019 May 1;11(1):38. doi: 10.1186/s13195-019-0491-2.

Serotonin (5-hydroxytryptamine or 5HT) is a hormone found in the pineal gland, the central nervous system, the digestive tract and platelets.

It is a neurotransmitter that regulates important functions such as:

• mood
• sleep
• blood vessels

The level and the system of serotonin are different between uommini and women in which the receptors are more consistent.

There are numerous studies on serotonin and on the effects linked to the contrast of depression (1), to diseases related to stress such as psoriasis (2) or hypertension (3).

Small amounts of serotonin can also be found in the peel of the hazelnut (4).

Serotonin studies

Molecular Formula: C₁₀H₁₂N₂O

Molecular Weight: 176.219 g/mol

UNII: 333DO1RDJY

CAS: 50-67-9

EC Number: 200-058-9

FEMA Number:

Synonyms:

• 5-Hydroxytryptamine
• 3-(2-Aminoethyl)-1H-indol-5-ol
• Hippophain
• Antemoqua
• Substance DS
• Substanz DS
• Enteramine
• 5-HT
• Antemovis
• Serotonine
• Thrombocytin
• Thrombotonin
• 3-(.beta.-Aminoethyl)-5-hydroxyindole
• 5-Hydroxy-3-(.beta.-aminoethyl)indole
• 5-Hydroxytryptamine, 5-HT, Enteramine
• 1H-Indol-5-ol, 3-(2-aminoethyl)-
• 5-Hta
• Tryptamine, 5-hydroxy-
• 3-(2-Aminoethyl)indol-5-ol
• Enteramin
• Indol-5-ol, 3-(2-aminoethyl)-

References_________________________________________

(1)  Serotonin-norepinephrine reuptake inhibitor therapy in late-life depression is associated with increased marker of bone resorption.
Shea ML, Garfield LD, Teitelbaum S, Civitelli R, Mulsant BH, Reynolds CF 3rd, Dixon D, Doré P, Lenze EJ.

(2) Serotonergic drugs--a possible role in the treatment of psoriasis?
Thorslund K, Nordlind K.
Drug News Perspect. 2007 Oct;20(8):521-5. Review.

(3) One-Month Serotonin Infusion Results in a Prolonged Fall in Blood Pressure in the Deoxycorticosterone Acetate (DOCA) Salt Hypertensive Rat.
Davis RP, Szasz T, Garver H, Burnett R, Tykocki NR, Watts SW.
ACS Chem Neurosci. 2013 Jan 16;4(1):141-8. doi: 10.1021/cn300114a. 

(4) Investigation of serotonin, free and protein-bound tryptophan in Turkish hazelnut varieties and effect of roasting on serotonin content.  Taş NG, Yılmaz C, Gökmen V.  Food Res Int. 2019 Jun;120:865-871. doi: 10.1016/j.foodres.2018.11.051