Methoxy PEG-100 is a chemical compound, polyethylene glycol (PEG (Polyethylene glycol)) ether of methoxyethanol attached to a variable length PEG (Polyethylene glycol) chain (100 ethylene glycol units). Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-methoxy-  

What it is used for and where

Cosmetics

Solvent. It is a substance for dissolving or dispersing surfactants, oils, dyes, flavourings, bactericidal preservatives in solution.

Humectant. Hygroscopic compound used to minimise water loss in the skin and to prevent it from drying out by facilitating faster and greater absorption of water into the stratum corneum of the epidermis.  The epidermis is the most superficial of the three layers that make up human skin (epidermis, dermis and hypodermis) and is the layer that maintains hydration in all three layers. In turn, the epidermis is composed of five layers: horny, the most superficial, granular, spinous, shiny, and basal. Humectants have the ability to retain the water they attract from the air in the stratum corneum and have the function of moisturising the skin. They are best used before emollients, which are oil-based. 

Since the PEG (Polyethylene glycol) family is very numerous and can be found in cosmetic, industrial, pharmaceutical, medical and other products, we need to make an introductory statement on the subject, which is rather complex from a safety point of view because these products not only come into contact with the skin, but, as in the case of medical products, are ingested.

PEGs (polyethylene glycol) polymerise condensed ethylene oxide and water and are referred to as polyethylene glycols, but are actually complex chemical components, polymers bonded together. For example, plastic is polyethylene and has a hard consistency, while polyethylene combined with glycol forms a liquid. PEGylation is produced not only as etherification, but also as transesterification, which is the transformation of an alcohol by an ester. 

The number appearing after the abbreviation PEG represents the molecular weight and the higher this number is, the less it penetrates the skin.

Safety. The term 'eth' refers to the ethoxylation reaction with ethylene oxide after which residues of ethylene oxide and 1,4-dioxane, chemical compounds considered carcinogenic, may remain. The degree of safety therefore depends on the degree of purity of the compound obtained. At present, no manufacturer is known to provide this information on the label.

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CAS: 9004-74-4