E538 (Calcium ferrocyanide) is a chemical compound obtained by reacting sodium ferrocyanide with calcium hydroxide

It appears as a whitish or yellowish crystalline powder, soluble in water.

What it is used for and where

Food

Ingredient included in the list of European food additives as E538 as an anti-caking agent to improve the quality of food salts.

Safety

EFSA's Panel on Food Additives provided a scientific opinion reviewing the safety of sodium ferrocyanide (E535), potassium ferrocyanide (E536) and evaluating the safety of calcium ferrocyanide (E538) as food additives. Exposure to ferrocyanides (E535-538) from their use as food additives was up to 0.009 mg/kg body weight (bw) per day in children and adolescents. In the refined estimated exposure scenario, the exposure was up to 0.003 mg/kg bw per day in children and adolescents. Absorption of ferrocyanides is low and there is no accumulation in humans. The Panel established a group Acceptable Daily Intake (ADI) for sodium, potassium and calcium ferrocyanide of 0.03 mg/kg bw per day expressed as ferrocyanide ion. The Panel concluded that ferrocyanides (E535-538) are of no safety concern at current authorised levels of use  (1).

Subsequent to this 2018 report, in 2019 a group of Dutch researchers conducted a study on the 'Pathways of Adverse Outcomes and Risk Assessment' of 326 food additives of which the majority are emulsifiers and stabilisers (87), acidity regulators and antioxidants (58). Some food additives were found to be nephrotoxic, including sodium, potassium and calcium ferrocyanide (E535, E536 and E538) (2).

Other uses

• wine clarification
• removal of iron and nickel

• Molecular Formula  Ca₂[Fe(CN)₆] · 12H₂O
• Molecular Weight     508.3 g/mol
• CAS  1327‐39‐5
• UNII   
• EC Number   215‐476‐7

References_____________________________________________________________________

(1) EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS); Younes M, Aggett P, Aguilar F, Crebelli R, Dusemund B, Filipič M, Frutos MJ, Galtier P, Gott D, Gundert-Remy U, Kuhnle GG, Lambré C, Leblanc JC, Lillegaard IT, Moldeus P, Mortensen A, Oskarsson A, Stankovic I, Waalkens-Berendsen I, Wright M, Di Domenico A, Van Loveren H, Giarola A, Horvath Z, Lodi F, Woutersen RA. Re-evaluation of sodium ferrocyanide (E 535), potassium ferrocyanide (E 536) and calcium ferrocyanide (E 538) as food additives. EFSA J. 2018 Jul 25;16(7):e05374. doi: 10.2903/j.efsa.2018.5374. 

(2) Kramer NI, Hoffmans Y, Wu S, Thiel A, Thatcher N, Allen TEH, Levorato S, Traussnig H, Schulte S, Boobis A, Rietjens IMCM, Vinken M. Characterizing the coverage of critical effects relevant in the safety evaluation of food additives by AOPs. Arch Toxicol. 2019 Aug;93(8):2115-2125. doi: 10.1007/s00204-019-02501-x.