Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76 is a compound of natural origin obtained from the plant Nicotiana benthamiana belonging to the botanical family Solanaceae.

The name describes the structure of the molecule

• "Nicotiana Benthamiana"refers to a species of tobacco plant, often used in biotechnology as a host system for protein and peptide production.
• "Hexa" indicates that it's a peptide made up of six amino acids. 
• "40" is a specific numeric identifier for this hexapeptide.
• "sh-Polypeptide-76". "sh" indicates "short hairpin", a specific RNA structure. 
• "Polypeptide" indicates a chain of amino acids
• "76" is a specific numeric identifier for this polypeptide.

Description of raw materials used in production

• Nicotiana Benthamiana. A type of tobacco plant used as a bioreactor in modern biotechnology.
• Hexapeptide-40 & sh-Polypeptide-76. Bio-engineered peptides derived from the Nicotiana Benthamiana plant.

Step-by-step summary of industrial chemical synthesis process

• Plant-Based Expression System. The tobacco plant cells are genetically modified to produce the desired peptides. These cells act as factories, synthesizing the peptides during their growth phase.
• Extraction & Purification. After reaching maturity, the plant cells are processed to extract the peptides. They are then purified through chromatography or other suitable methods.

What it is for and where

Cosmetics

Skin conditioning agent. It is the mainstay of topical skin treatment as it has the function of restoring, increasing or improving skin tolerance to external factors, including melanocyte tolerance. The most important function of the conditioning agent is to prevent skin dehydration, but the subject is rather complex and involves emollients and humectants that can be added in the formulation.

Commercial applications

Cosmetic Industry. These peptides are valued for their potential anti-aging, skin rejuvenating, and cellular boosting properties. They may be found in serums, creams, and other skincare formulations.

Properties and Benefits.

Anti-Aging. They may promote collagen synthesis, aiding in skin firmness and elasticity.

Skin Rejuvenation. Stimulate cellular turnover and regeneration.

Biocompatible. Being plant-derived, these peptides tend to be well-tolerated by the skin.

References__________________________________________________________________________

Bally J, Jung H, Mortimer C, Naim F, Philips JG, Hellens R, Bombarely A, Goodin MM, Waterhouse PM. The Rise and Rise of Nicotiana benthamiana: A Plant for All Reasons. Annu Rev Phytopathol. 2018 Aug 25;56:405-426. doi: 10.1146/annurev-phyto-080417-050141.

Abstract. A decade ago, the value of Nicotiana benthamiana as a tool for plant molecular biologists was beginning to be appreciated. Scientists were using it to study plant-microbe and protein-protein interactions, and it was the species of choice with which to activate plasmid-encoded viruses, screen for gene functions with virus-induced gene silencing (VIGS), and transiently express genes by leaf agroinfiltration. However, little information about the species' origin, diversity, genetics, and genomics was available, and biologists were asking the question of whether N. benthamiana is a second fiddle or virtuoso. In this review, we look at the increased knowledge about the species and its applications over the past decade. Although N. benthamiana may still be the sidekick to Arabidopsis, it shines ever more brightly with realized and yet-to-be-exploited potential.

Goodin MM, Zaitlin D, Naidu RA, Lommel SA. Nicotiana benthamiana: its history and future as a model for plant-pathogen interactions. Mol Plant Microbe Interact. 2008 Aug;21(8):1015-26. doi: 10.1094/MPMI-21-8-1015. 

Abstract. Nicotiana benthamiana is the most widely used experimental host in plant virology, due mainly to the large number of diverse plant viruses that can successfully infect it. Additionally, N. benthamiana is susceptible to a wide variety of other plant-pathogenic agents (such as bacteria, oomycetes, fungi, and so on), making this species a cornerstone of host-pathogen research, particularly in the context of innate immunity and defense signaling. Moreover, because it can be genetically transformed and regenerated with good efficiency and is amenable to facile methods for virus-induced gene silencing or transient protein expression, N. benthamiana is rapidly gaining popularity in plant biology, particularly in studies requiring protein localization, interaction, or plant-based systems for protein expression and purification. Paradoxically, despite being an indispensable research model, little is known about the origins, genetic variation, or ecology of the N. benthamiana accessions currently used by the research community. In addition to addressing these latter topics, the purpose of this review is to provide information regarding sources for tools and reagents that can be used to support research in N. benthamiana. Finally, we propose that N. benthamiana is well situated to become a premier plant cell biology model, particularly for the virology community, who as a group were the first to recognize the potential of this unique Australian native.

Reed J, Osbourn A. Engineering terpenoid production through transient expression in Nicotiana benthamiana. Plant Cell Rep. 2018 Oct;37(10):1431-1441. doi: 10.1007/s00299-018-2296-3. 

Abstract. Terpenoids are the most structurally diverse class of plant natural products with a huge range of commercial and medical applications. Exploiting this enormous potential has historically been hindered due to low levels of these compounds in their natural sources, making isolation difficult, while their structural complexity frequently makes synthetic chemistry approaches uneconomical. Engineering terpenoid biosynthesis in heterologous host production platforms provides a means to overcome these obstacles. In particular, plant-based production systems are attractive as they provide the compartmentalisation and cofactors necessary for the transfer of functional pathways from other plants. Nicotiana benthamiana, a wild relative of tobacco, has become increasingly popular as a heterologous expression platform for reconstituting plant natural product pathways, because it is amenable to Agrobacterium-mediated transient expression, a scalable and highly flexible process that enables rapid expression of genes and enzymes from other plant species. Here, we review recent work describing terpene production in N. benthamiana. We examine various strategies taken to engineer this host for increased production of the target metabolite. We also look at how transient expression can be utilised for rapid generation of molecular diversity, including new-to-nature products. Finally, we highlight current issues surrounding this expression platform and discuss the future directions and developments which will be needed to fully realise the potential of this system.