Bifida Ferment Lysate is a naturally derived cosmetic ingredient derived from the fermentation of Bifidobacterium bacteria and is considered a probiotic.

The name describes the structure of the molecule:

• Bifida refers to Bifidobacterium, a genus of bacteria that is part of the human gut flora. These bacteria are known for their health benefits to the intestinal tract and the immune system.
• Ferment indicates that the bacteria have been fermented, a biological process that transforms sugars into lactic acid or other substances, enhancing the properties of the product.
• Lysate refers to a product that has been obtained from lysis, which is the breaking down of cells to release their content.

Industrial Production Process

• Strain selection. A specific strain of Bifida bacteria is selected for its beneficial properties and its ability to survive the fermentation process.
• Culture medium preparation. A nutrient-rich culture medium that supports the optimal growth of Bifida bacteria is prepared.
• Fermentation. The Bifida bacteria are inoculated into the culture medium and allowed to ferment under controlled conditions of temperature and pH for a set period, allowing for the production of a biomass rich in beneficial components.
• Cell lysis. After fermentation, the bacterial cells undergo lysis, a process that breaks down the cell walls to release the intracellular contents, forming the lysate.
• Filtration. The lysate is filtered to remove dead cell particles and other residues, thereby purifying the product.
• Quality control. The obtained Bifida Ferment Lysate undergoes rigorous quality testing to ensure the presence of active components, microbiological purity, and the absence of contaminants.
• Storage. The final product is stored under conditions that maintain its stability and efficacy until its use in the finished product.

What it is used for and where

Bifida Ferment Lysate is valued for its reparative and protective properties on the skin. This ingredient helps to improve the skin barrier, reducing skin sensitivity and enhancing its defense capability against environmental stress factors. It is often used in products intended for the care of mature or damaged skin, such as serums and moisturizing creams, for its effectiveness in improving skin elasticity and appearance, as well as reducing visible signs of aging.

Cosmetics - INCI Functions

• Skin conditioning agent. It is the mainstay of topical skin treatment as it has the function of restoring, increasing or improving skin tolerance to external factors, including melanocyte tolerance. The most important function of the conditioning agent is to prevent skin dehydration, but the subject is rather complex and involves emollients and humectants that can be added in the formulation.

CAS    96507-89-0

EC number    306-168-4

Main uses and benefits of Bifida Ferment Lysate.

DNA Repair. This ingredient helps repair cellular DNA damaged by exposure to UV rays and other harmful environmental factors, contributing to the prevention of premature skin aging (1).

Strengthening the Skin Barrier. It improves the functionality of the skin barrier, increasing its ability to retain moisture and protecting it from external irritants (2).

Moisturizing Properties. It provides deep hydration to the skin, improving its texture and reducing the appearance of fine lines and wrinkles.

Anti-inflammatory Effects. It has anti-inflammatory properties that can help reduce redness and irritation, making it ideal for sensitive or compromised skin (3).

Skin Regeneration. It stimulates cell renewal and skin regeneration, helping to keep the skin youthful and radiant.

Versatile Applications. It can be used in a wide range of skincare products, including serums, creams, masks, and lotions, due to its effectiveness and skin benefits.

References_____________________________________________________________________

(1) Ácsová, A., Hojerová, J., & Martiniaková, S. (2022). Efficacy of postbiotics against free radicals and UV radiation. Chemical Papers, 76(4), 2357-2364.

Abstract. The importance of probiotics for the internal and external human microbiota has already been scientifically confirmed. As these are viable bacteria, the direct dermal use of them through mass-produced cosmetics is impossible. For these purposes, postbiotics—substances derived from probiotics through fermentation processes—appear to be promising. Two postbiotics have been investigated in vitro for their protective ability against free radicals and UV radiation compared to conventional synthetic chemicals. Lactococcus Ferment Lysate and Bifida Ferment Lysate in 5% aqueous solution and 100% concentrate were able to scavenge from 0.15 to 54.2% and 7.0 to 71.0%, respectively, of 2,2-diphenyl-1-picrylhydrazyl radical. L. Ferment Lysate in the emulsion, the composition of which is a reference in testing the effectiveness of sunscreen products with a low SPF value, showed an absorption capacity in the UVB region (SPF 4.75) comparable to the standard chemical UV filter Homomenthyl salicylate (SPF value of 4.45) and in the UVA region better than this standard. The UV absorption ability of B. Ferment Lysate was negligible. Postbiotics B. Ferment Lysate and L. Ferment Lysate are beneficial natural active ingredients for the skin protection against free radicals and L. Ferment Lysate also against UVB + UVA radiation.

(2) Wang R, Yan S, Ma X, Zhao J, Han Y, Pan Y, Zhao H. The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro. J Cosmet Dermatol. 2023 Dec;22(12):3427-3435. doi: 10.1111/jocd.15831. Epub 2023 May 23. PMID: 37218728.

(3) Fabbrocini G, Ferrillo M, Donnarumma M, Papale A, Pinto D, Rinaldi F. A Randomized, Double-Blind, Placebo-Controlled, Multicentric Study to Evaluate the Efficacy and the Tolerability of a Class II Medical Device in the Treatment of Mild and Moderate Acne. Dermatol Ther (Heidelb). 2022 Aug;12(8):1835-1845. doi: 10.1007/s13555-022-00767-1.