Tripeptide-85 is a chemical compound, a synthetic peptide, and a molecule composed of three amino acids linked together: glutamine, phenylalanine and valine.
Peptides are substances consisting of two or more amino acids linked together by a linear chain. Synthetic peptides can be generated as copies of protein fragments by incorporating non-proteinogenic amino acids and modified so as to also increase the proteolytic stability of the molecules.
What it is used for and where
Cosmetics
- Deodorant agent. When substances that give off an unpleasant odour are included in cosmetic formulations (typical examples are methyl mercaptan and hydrogen sulphide derived from garlic), deodorants attenuate or eliminate the unpleasant exhalation. It helps counteract the formation of bad odours on body surfaces.
- Skin conditioning agent - Miscellaneous. This ingredient has the task of modifying and improving the condition of the skin when it is damaged or dry, reducing flaking and restoring its elasticity.
Tripeptide-85 is an active ingredient used in cosmetic formulations for its ability to stimulate collagen production, a key component for maintaining firm and elastic skin. This peptide helps to reduce signs of aging, such as wrinkles and fine lines, by improving the skin's structure and promoting a younger, more radiant appearance. It is particularly effective in anti-aging products like serums, creams, and intensive treatments, where it provides regenerative benefits and helps maintain smooth and resilient skin.
Medical
Tripeptides and dipeptides have proven useful in biomedical applications (1) and for sensitive skin (2).
Molecular Formula C19H27N3O6
Molecular Weight 393.4 g/mol
CAS 31461-61-7
DTXSID70953473
References_____________________________________________________________________
(1) Santos S, Torcato I, Castanho MA. Biomedical applications of dipeptides and tripeptides. Biopolymers. 2012;98(4):288-93. doi: 10.1002/bip.22067. PMID: 23193593.
Abstract. Peptides regulate many physiological processes, acting at some sites as endocrine or paracrine signals and at others as neurotransmitters or growth factors, for instance. These molecules represent a major evolution in medical and industrial fields, as it is becoming mandatory to design and exploit molecules that do not necessarily fit the description of classical drug classes. The list of peptides with potential biomedical applications is huge and is growing each year. These biomedical applications range from uses as drugs to flavor-active peptides as ingredients in natural health products, nutraceuticals and functional foods. Among the peptide family, dipeptides and tripeptides are very appealing for drug discovery and development because of their cost-effectiveness, possibility of oral administration, and simplicity to perform molecular structural and quantitative structure-activity studies. Our objective is to review different actual and future uses of dipeptides and tripeptides as well as the major advances and obstacles in this growing area.
(2) Resende DISP, Ferreira MS, Sousa-Lobo JM, Sousa E, Almeida IF. Usage of Synthetic Peptides in Cosmetics for Sensitive Skin. Pharmaceuticals (Basel). 2021 Jul 21;14(8):702. doi: 10.3390/ph14080702.
Abstract. Sensitive skin is characterized by symptoms of discomfort when exposed to environmental factors. Peptides are used in cosmetics for sensitive skin and stand out as active ingredients for their ability to interact with skin cells by multiple mechanisms, high potency at low dosage and the ability to penetrate the stratum corneum. This study aimed to analyze the composition of 88 facial cosmetics for sensitive skin from multinational brands regarding usage of peptides, reviewing their synthetic pathways and the scientific evidence that supports their efficacy. Peptides were found in 17% of the products analyzed, namely: acetyl dipeptide-1 cetyl ester, palmitoyl tripeptide-8, acetyl tetrapeptide-15, palmitoyl tripeptide-5, acetyl hexapeptide-49, palmitoyl tetrapeptide-7 and palmitoyl oligopeptide. Three out of seven peptides have a neurotransmitter-inhibiting mechanism of action, while another three are signal peptides. Only five peptides present evidence supporting their use in sensitive skin, with only one clinical study including volunteers having this condition. Noteworthy, the available data is mostly found in patents and supplier brochures, and not in randomized placebo-controlled studies. Peptides are useful active ingredients in cosmetics for sensitive skin. Knowing their efficacy and synthetic pathways provides meaningful insight for the development of new and more effective ingredients.
Tripeptide-85 
