Sodium Hyaluronate Crosspolymer-3 is a chemical compound, a special form of hyaluronic acid used in various cosmetic and personal care products. This polymer is created by oxidizing hyaluronic acid to facilitate subsequent crosslinking with propylbisoxyamine, enhancing its moisturizing and anti-aging properties, and providing long-lasting hydration and improved skin elasticity.

Chemical Composition and Structure

Sodium Hyaluronate Crosspolymer-3 is the sodium salt of hyaluronic acid that has been oxidized to enable crosslinking with propylbisoxyamine. This process forms a three-dimensional network that significantly enhances the molecule's ability to retain water, offering sustained hydration. The chemical structure includes oxidized hyaluronic acid molecules interconnected by propylbisoxyamine, creating a robust and flexible polymer network.

Physical Properties

Sodium Hyaluronate Crosspolymer-3 typically appears as a white or off-white powder. It is highly soluble in water, forming a gel-like substance when hydrated. This gel provides a smooth, non-greasy texture, making it suitable for various cosmetic formulations. The crosslinked structure offers improved stability and a controlled release of moisture over time.

Chemical Industrial Synthesis Process

• Preparation of reagents. The main raw materials include hyaluronic acid (HA), sodium chloride (NaCl), an oxidizing agent such as hydrogen peroxide (H₂O₂) or sodium periodate (NaIO₄), and propylbisoxyamine as the crosslinking agent.
• Solubilization. Hyaluronic acid is solubilized in an aqueous sodium chloride solution to obtain a sodium hyaluronate solution.
• Oxidation. The oxidizing agent is added to the sodium hyaluronate solution under continuous stirring. The mixture is maintained at a controlled temperature (approximately 20-25°C) to allow the oxidation reaction, which introduces aldehyde groups onto the hyaluronic acid.
• Addition of crosslinking agent. After oxidation, propylbisoxyamine is added to the oxidized sodium hyaluronate solution under continuous stirring.
• Crosslinking reaction. The mixture is maintained at a controlled temperature (approximately 20-25°C) to allow the crosslinking reaction between the oxidized aldehyde groups and propylbisoxyamine. This reaction forms the sodium hyaluronate crosspolymer-3.
• Neutralization. The reaction mixture is neutralized with a sodium hydroxide (NaOH) solution to ensure the pH is neutral.
• Dialysis. The crosspolymer solution is dialyzed against distilled water to remove residual salts and unreacted crosslinking agents.
• Concentration. The dialyzed solution is concentrated by vacuum evaporation to obtain a more concentrated sodium hyaluronate crosspolymer-3 solution.
• Drying. The concentrated solution is dried by lyophilization to obtain a dry product.
• Grinding. The dried product is ground to obtain a fine and uniform powder.
• Classification. The dried powder is classified to ensure a uniform particle size. This step may involve sieving or the use of air classifiers.
• Stabilization. The sodium hyaluronate crosspolymer-3 is stabilized to ensure its stability during transportation and storage, preventing aggregation and degradation.
• Quality control. The sodium hyaluronate crosspolymer-3 undergoes rigorous quality testing to ensure it meets standards for purity, safety, and functionality. These tests include chemical analysis, spectroscopy, and physical tests to determine particle size and rheological properties.

What it is used for and where

Cosmetics - INCI Functions

Humectant. Hygroscopic compound used to minimise water loss in the skin and to prevent it from drying out by facilitating faster and greater absorption of water into the stratum corneum of the epidermis.  The epidermis is the most superficial of the three layers that make up human skin (epidermis, dermis and hypodermis) and is the layer that maintains hydration in all three layers. In turn, the epidermis is composed of five layers: horny, the most superficial, granular, spinous, shiny, and basal. Humectants have the ability to retain the water they attract from the air in the stratum corneum and have the function of moisturising the skin. They are best used before emollients, which are oil-based.

Skin conditioning agent. It is the mainstay of topical skin treatment as it has the function of restoring, increasing or improving skin tolerance to external factors, including melanocyte tolerance. The most important function of the conditioning agent is to prevent skin dehydration, but the subject is rather complex and involves emollients and humectants that can be added in the formulation.

Applications

Moisturizers and Creams: Sodium Hyaluronate Crosspolymer-3 is widely used in moisturizers and creams for its ability to provide long-lasting hydration. It forms a protective barrier on the skin, reducing transepidermal water loss and keeping the skin hydrated.

Anti-Aging Products: Due to its excellent water retention properties, this ingredient is commonly found in anti-aging products. It helps to plump the skin, reducing the appearance of fine lines and wrinkles, and improving overall skin elasticity.

Serums and Essences: In serums and essences, Sodium Hyaluronate Crosspolymer-3 acts as a powerful hydrating agent, enhancing the delivery and effectiveness of active ingredients.

Sun Care: It is also used in sun care products to provide hydration and soothing effects, helping to protect the skin from the drying effects of sun exposure.

Eye Creams and Gels: The ingredient is ideal for use in eye creams and gels due to its gentle yet effective moisturizing properties, helping to reduce puffiness and dark circles.

Safety

Sodium Hyaluronate Crosspolymer-3 is generally considered safe for use in cosmetic and personal care products. It is non-irritating and suitable for all skin types, including sensitive skin. The ingredient is biodegradable and poses minimal risk to the environment when disposed of properly. As with all cosmetic ingredients, it is important to use it within the recommended guidelines to ensure safety and efficacy.