Lactoperoxidase is an enzyme naturally found in milk and various other bodily fluids, such as saliva and tears. This enzyme is part of the peroxidase family and plays a crucial role in the body’s immune system by exhibiting antimicrobial properties. Lactoperoxidase is widely used in the cosmetic and personal care industry for its ability to enhance product preservation, improve skin condition, and provide antimicrobial benefits.

Chemical Composition and Structure
Lactoperoxidase is a heme-containing enzyme composed of a single polypeptide chain. Its active site contains an iron ion coordinated to a heme prosthetic group, which is essential for its enzymatic activity. The enzyme's primary structure includes:

Amino Acids: The building blocks of the enzyme that form its polypeptide chain.
Heme Group: An iron-containing prosthetic group crucial for its catalytic activity.
Glycoproteins: Contribute to the stability and functionality of the enzyme.
Physical Properties
Lactoperoxidase typically appears as a white to off-white powder or crystalline substance when isolated and purified. It is soluble in water, which makes it easy to incorporate into various cosmetic formulations.

Cosmetic and Personal Care Applications
Antimicrobial: Lactoperoxidase exhibits strong antimicrobial properties, helping to inhibit the growth of bacteria, fungi, and other pathogens on the skin and in cosmetic products.

Preservative Enhancement: It is often used in combination with other preservatives to enhance their effectiveness and extend the shelf life of cosmetic and personal care products.

Skin Conditioning: Lactoperoxidase helps improve skin condition by promoting a healthy skin microbiome and reducing the risk of infections.

Anti-Inflammatory: The enzyme has anti-inflammatory properties that can help soothe irritated or inflamed skin, making it beneficial for sensitive skin formulations.

Oral Care: In oral care products, lactoperoxidase helps maintain oral hygiene by reducing the bacterial load in the mouth, preventing bad breath, and promoting gum health.

Wound Healing: Due to its antimicrobial and anti-inflammatory properties, lactoperoxidase can aid in wound healing and skin repair.

Environmental and Safety Considerations

Lactoperoxidase is generally considered safe for use in cosmetic and personal care products. It is naturally occurring and biodegradable, posing minimal risk to the environment. However, as with all enzymes, it should be handled carefully to avoid potential allergic reactions or irritation in sensitive individuals.

Cosmetics - INCI Functions


Light stabilizer. It prevents light from degrading light-sensitive components and slows down degradation reactions that have already begun. The mechanism is, in a way, similar to antioxidants and the effectiveness depends on the.complexity of the formulation and the density of the product.
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CAS: 9003-99-0 EC number 232-668-6