Toxicity of food sweetener-sodium cyclamate on osteoblasts cells.
Chen Z, Chen G, Zhou K, Zhang P, Ren X, Mei X.
Biochem Biophys Res Commun. 2019 Jan 8;508(2):507-511. doi: 10.1016/j.bbrc.2018.11.172.

Genomic resolution of bacterial populations in saccharin and cyclamate degradation.
Deng Y, Wang Y, Xia Y, Zhang AN, Zhao Y, Zhang T.
Sci Total Environ. 2019 Mar 25;658:357-366. doi: 10.1016/j.scitotenv.2018.12.162.

Validation of an HPLC-DAD/UV method for the quantification of cyclamate in tabletop sweeteners: risk of exceeding the acceptable daily intake.
Sargaço B, Serra C, Vasco E.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2017 Jun;34(6):883-890. doi: 10.1080/19440049.2017.1306756

Use of two artificial sweeteners, cyclamate and acesulfame, to identify and quantify wastewater contributions in a karst spring.
Zirlewagen J, Licha T, Schiperski F, Nödler K, Scheytt T.
Sci Total Environ. 2016 Mar 15;547:356-365. doi: 10.1016/j.scitotenv.2015.12.112.

Rapid analysis of cyclamate in foods and beverages by gas chromatography-electron capture detector (GC-ECD).
Yu S, Zhu B, Lv F, Li S, Huang W.
Food Chem. 2012 Oct 15;134(4):2424-9. doi: 10.1016/j.foodchem.2012.04.028.

Stevia, cyclamate and saccharin - natural and artificial sweeteners - exert no effect on sulfane levels in tissues.
Wilinski B, Opoka W, Somogyi E, Piotrowska J, Wilinski J.
Folia Med Cracov. 2013;53(3):37-42.

Cyclamate is a chemical compound, a sweetener, discovered in 1937 from research by the University of Illinois and is therefore among the oldest sweeteners on the market.

With the number E952 on the list of food additives, it is considered a controversial substitute for sugar because in 1956 the FDA (Food and Drug Administration) prohibited the use of this component in the food sector.

Raw Materials and Their Functions

Cyclamic Acid is the base for the production of cyclamate. This acid is neutralized with a base to form cyclamate salt, which is the form commonly used in food products.

Industrial Chemical Synthesis of Cyclamate

• Neutralization. The process begins with the neutralization of cyclamic acid with a base, such as sodium or calcium, to form sodium or calcium cyclamate.
• Reaction Control. The neutralization reaction is monitored to ensure that the ratio of cyclamic acid to the base is correct and the desired salt is formed.
• Purification. After the reaction, cyclamate is purified to remove impurities and by-products.
• Quality Control. The purified cyclamate undergoes quality checks to ensure it meets the required standards. After quality control, it is packaged for use in food products and beverages as a low-calorie sweetener.

Form and Color

 Cyclamate is typically a solid in the form of crystalline powder usually white.

Commercial Applications

 Cyclamate is primarily used as an artificial sweetener in various food products and beverages. It is known to be many times sweeter than sugar but with fewer calories. It is used in products such as soft drinks, sweets, jams, jellies, and in some pharmaceutical products. However, it is important to note that the use of cyclamate is subject to restrictions and bans in some countries due to safety concerns.

Cyclamate studies

Molecular Formula: C₆H₁₃NO₃S

Molecular Weight: 179.234 g/mol

UNII: HN3OFO5036

CAS: 100-88-9   45951-45-9

EC Number: 202-898-1

PubChem Substance ID 329749471

MDL number MFCD00065234

Beilstein Registry Number 2208885

Synonyms:

• Cyclamic acid
• E952
• Cyclohexylsulfamic acid
• N-Cyclohexylsulphamic acid
• Cyclohexylamidosulfuric acid
• Cyclohexylaminesulfonic acid
• Cylamic acid
• Cyclohexylsulphamic acid
• Cyclohexanesulphamic acid
• Cyclohexylsulfamate
• Cyclohexylamine sulfamic acid
• 100-88-9
• Cyclohexanesulfamic acid
• N-Cyclohexylsulfamic acid
• CYCLAMATE
• Hexamic acid
• Sucaryl
• Sucaryl acid
• Cyclohexylaminesulphonic acid
• Sulfamic acid, cyclohexyl-
• Polycat 200
• Zyklamat
• Cyclohexylamidosulphuric acid
• Cyclohexylamide sulfate
• Sulfamic acid, N-cyclohexyl-