Ziziphus jujuba, commonly referred to as jujube or Chinese date, is a deciduous tree or shrub in the buckthorn family (Rhamnaceae). Native to China and widely cultivated throughout Asia, the Middle East, and Mediterranean regions, this plant is prized for its small, edible, and nutrient-rich fruits. The jujube fruit has been used for thousands of years in traditional medicine for its calming, digestive, and immune-boosting properties.

Botanical Classification

• Kingdom: Plantae
• Clade: Angiosperms
• Class: Eudicots
• Order: Rosales
• Family: Rhamnaceae
• Genus: Ziziphus
• Species: Ziziphus jujuba

Plant Characteristics

Ziziphus jujuba is a small to medium-sized tree with the following features:

• Height: Grows up to 5–12 meters in height, depending on the variety and growing conditions.
• Leaves: Oval, glossy green leaves with fine serrations, which turn yellow in autumn.
• Flowers: Small, yellow-green, and fragrant flowers bloom in clusters during late spring and early summer.
• Fruits: Round to oval drupes, ranging from 2–3 cm in diameter. The skin is smooth and turns from green to reddish-brown when ripe. The flesh is sweet, crisp when fresh, and becomes chewy and date-like when dried.
• Roots: Deep-rooted, making it drought-tolerant.
• Habitat: Thrives in warm, arid, or semi-arid climates, often grown in sandy, loamy, or well-drained soils.

Chemical Composition and Structure

The jujube fruit is rich in bioactive compounds, including:

• Flavonoids: Quercetin, rutin, and kaempferol, which contribute to its antioxidant properties.
• Polysaccharides: Found in the fruit pulp, beneficial for immune modulation and energy.
• Saponins: Particularly in the seeds, known for their calming and sedative effects.
• Vitamins: High in vitamin C, B vitamins, and small amounts of vitamin A.
• Minerals: Rich in potassium, magnesium, iron, and calcium.
• Phenolic Acids: Contributing to its anti-inflammatory and antimicrobial effects.

How to Cultivate Ziziphus jujuba

Cultivating Ziziphus jujuba requires attention to its environmental needs:

1. Climate: Thrives in warm, sunny climates with minimal frost. It can tolerate temperatures as low as -15°C during dormancy.
2. Soil Requirements: Prefers well-drained, sandy, or loamy soils with a slightly alkaline to neutral pH. It is drought-tolerant but performs best with occasional irrigation.
3. Propagation: Propagated by seeds, root cuttings, or grafting. Grafted plants tend to produce better fruit quality.
4. Watering and Maintenance: Requires moderate watering during the growing season. Mature trees are drought-tolerant. Pruning is recommended in late winter to shape the tree and remove dead branches.
5. Harvesting: Fruits are harvested when fully ripe, typically in late summer or early autumn. They can be eaten fresh, dried, or processed.

Uses and Benefits

The jujube tree offers a variety of uses, ranging from culinary to medicinal:

• Culinary Uses:

  • Fresh Fruit: Eaten as a snack for its sweet and crisp taste.
  • Dried Fruit: Often used in teas, soups, desserts, and as a natural sweetener.
  • Juices and Jams: Processed into beverages, jams, and candies.

• Medicinal Benefits:

  • Calming Effects: Used in traditional medicine as a natural sedative to treat anxiety, insomnia, and stress.
  • Immune Support: Rich in vitamin C and polysaccharides, which boost immune function.
  • Digestive Aid: The fruit is known for its mild laxative properties and its ability to soothe the stomach.
  • Anti-inflammatory: The fruit and seeds contain compounds that reduce inflammation and oxidative stress.
  • Blood Circulation: Its high iron content supports red blood cell production.

• Ornamental Uses:

  • Often planted in gardens and parks for its attractive foliage and fragrant flowers.

Applications

• Medical:

  • Commonly used in traditional Chinese medicine for tonifying the spleen, calming the mind, and nourishing the blood.
  • Prepared as herbal teas, tinctures, or powders for treating insomnia, stress, and fatigue.

• Cosmetic:

  • Extracts of jujube are included in skincare products for their antioxidant and moisturizing properties.
  • The seed oil is used in hair care for nourishing and strengthening hair.

• Culinary:

  • Widely used in Asian and Middle Eastern cuisines in desserts, teas, and syrups.
  • Fermented into wine or vinegar in some cultures.

Environmental and Safety Considerations

Ziziphus jujuba is an environmentally friendly plant due to its low water requirements and ability to thrive in poor soils. However:

• Environmental Benefits: Helps prevent soil erosion and provides food for pollinators such as bees.
• Safety: The fruit is generally safe for consumption. However, excessive consumption may cause mild digestive discomfort in some individuals.
• Conservation: In certain areas, sustainable cultivation practices are encouraged to preserve traditional varieties and prevent overharvesting in the wild.

References__________________________________________________________________________

Popstoyanova D, Gerasimova A, Gentscheva G, Nikolova S, Gavrilova A, Nikolova K. Ziziphus jujuba: Applications in the Pharmacy and Food Industry. Plants (Basel). 2024 Sep 29;13(19):2724. doi: 10.3390/plants13192724. 

Abstract. Ziziphus jujuba has been used since ancient times in traditional Eastern medicine. It is widely cultivated in numerous countries between the tropical and temperate climatic zones due to its high ecological plasticity and resilience to adverse weather. The different classes of chemical compounds contained in the plant are the reason for its medicinal properties. Research shows that every part of Ziziphus jujuba, the leaves, fruits and seeds, demonstrate therapeutic properties. This review focuses on the chemical composition in order to establish the relationship between the plant and its clinical use. Various biological effects are summarized and discussed: anticancer, anti-inflammatory, immunostimulating, antioxidant, hepatoprotective, gastrointestinal, etc. Apart from medicinal uses, the fruits of Ziziphus jujuba are edible and used in fresh and dried form. This literature review reveals possible medical applications of Ziziphus jujuba and its great potential for improving the diet of people in areas where the plant is abundant.

Periasamy S, Wu WH, Chien SP, Liu CT, Liu MY. Dietary Ziziphus jujuba Fruit Attenuates Colitis-Associated Tumorigenesis: A Pivotal Role of the NF-κB/IL-6/JAK1/STAT3 Pathway. Nutr Cancer. 2020;72(1):120-132. doi: 10.1080/01635581.2019.1615515. 

Abstract. Inflammatory bowel disease (IBD) including ulcerative colitis (UC) is one of the risk factors for the development of colitis-associated colon cancer (CAC). CAC is a type of colorectal cancer (CRC), the third leading cause of cancer death. Ziziphus jujuba (ZJ) fruit contains bioactive components such as polysaccharides, triterpenoid acid, and flavonoids, and it has shown anti-inflammatory property. The aim of the study was to investigate the protective effect of dietary ZJ on colitis-associated colorectal tumorigenesis in mice. Mice (n = 42, two sets) were injected with azoxymethane (AOM) followed by three cycles of 2% (w/v) dextran sulfate sodium (DSS) in drinking water to induce CAC. Simultaneously, those mice were fed with ZJ diet for 70 days (5% or 10% w/w). Data were analyzed by ANOVA followed by LSD Bonferroni test. Dietary ZJ decreased fecal blood, diarrhea, disease activity index (DAI), spleen weight (P < 0.001), and the number of tumors (P < 0.001). In addition, dietary ZJ increased colon length (P < 0.001) and suppressed the activation of NF-кB/IL-6/JAK1/STAT3 signaling pathway. In conclusion, we suggest that dietary ZJ attenuates inflammation by interfering NF-κB/IL-6/JAK1/STAT3 signaling pathway, thereby inhibits AOM/DSS-induced colon tumorigenesis in mice.

Goswami P, Banerjee R, Mukherjee A. Potential antigenotoxicity assessment of Ziziphus jujuba fruit. Heliyon. 2019 May 18;5(5):e01768. doi: 10.1016/j.heliyon.2019.e01768. 

Abstract. Ziziphus jujuba Mill. fruits are nutritionally rich and have a broad spectrum of health benefits. In this work we hypothesized that this natural product rich in polyphenols might protect humans against DNA damage and its consequences. This has led to our investigation to find out if the fruit extract showed an ability to decrease the frequency of DNA damage (antigenotoxicity) induced by two known genotoxins namely an alkylating agent methyl methane sulphonate (MMS) and a reactive oxygen species (ROS) inducer hydrogen peroxide (H2O2). Human lymphocytes were incubated with the Ziziphus fruit ethanol extracts (ZFE) or betulinic acid (BA) followed by an exposure to either 50 μM of MMS or 250 μM of H2O2. Results suggest that ZFE (250, 500, 1000 μg/ml) and BA (10, 20, 40 μg/ml) were able to inhibit the DNA damaging effect caused by MMS and H2O2 indicative of their protection against the genotoxin. This could be attributed to the interactions of the phenolics, flavonoid and BA present in the fruits. Additional in vivo experiments were carried since BA is an important phytochemical detected in ample amounts in the fruit extract. Mice were primed with BA (2.5, 5.0 and 10 mg/kg body weight) for a period of 6 days. The animals were injected with MMS (10 mg/kg body weight) 24 h later and sacrificed. The genotoxic activity of MMS was inhibited in a dose - related manner by BA. BA reduced the frequency of MMS - induced DNA damage in liver, kidney and bone marrow cells of mice thereby exhibiting its antigenotoxic properties. It could also reduce total glutathione level, lipid peroxidation and hydrogen peroxide content in liver cells of mice through the up-regulation of antioxidant enzymes. Therefore taking into account the antioxidant and antigenotoxic properties, the consumption of the Ziziphus fruit should be more popularized worldwide.

Lu Y, Bao T, Mo J, Ni J, Chen W. Research advances in bioactive components and health benefits of jujube (Ziziphus jujuba Mill.) fruit. J Zhejiang Univ Sci B. 2021 Jun 15;22(6):431-449. doi: 10.1631/jzus.B2000594.

Abstract. Jujube (Ziziphus jujuba Mill.), a highly nutritious and functional fruit, is reported to have various health benefits and has been extensively planted worldwide, especially in China. Many studies have shown that bioactive components derived from jujube fruit have significant nutritional and potential biological effects. In this paper, the latest progress in research on major bioactive compounds obtained from jujube is reviewed, and the potential biological functions of jujube fruit resources are discussed. As a dietary supplement, jujube fruit is well recognized as a healthy food which contains a variety of bioactive substances, such as polysaccharides, polyphenols, amino acids, nucleotides, fatty acids, dietary fiber, alkaloids, and other nutrients. These nutrients and non-nutritive phytochemicals obtained from jujube fruit have physiological functions including anticancer, antioxidant, anti-inflammatory, anti-hyperlipidemic, anti-hyperglycemic, immunoregulatory, neuroprotective, sedative, and antiviral functions. Of note is that new constituents, including alkaloids, dietary fiber, and other bioactive substances, as well as the antiviral, hypoglycemic, lipid-lowering, and neuroprotective effects of jujube fruit, are systematically reviewed here for the first time. Meanwhile, problems affecting the exploitation of jujube fruit resources are discussed and further research directions proposed. Therefore, this review provides a useful bibliography for the future development of jujube-based products and the utilization of jujube nutritional components in functional foods.

Gao QH, Wu CS, Wang M. The jujube (Ziziphus jujuba Mill.) fruit: a review of current knowledge of fruit composition and health benefits. J Agric Food Chem. 2013 Apr 10;61(14):3351-63. doi: 10.1021/jf4007032.

Abstract. The nutritional jujube ( Ziziphus jujube Mill.) fruit belonging to the Rhamnaceous family grows mostly in Europe, southern and eastern Asia, and Australia, especially the inland region of northern China. Jujube has a long history of usage as a fruit and remedy. The main biologically active components are vitamin C, phenolics, flavonoids, triterpenic acids, and polysaccharides. Recent phytochemical studies of jujube fruits have shed some light on their biological effects, such as the anticancer, anti-inflammatory, antiobesity, immunostimulating, antioxidant, hepatoprotective, and gastrointestinal protective activities and inhibition of foam cell formation in macrophages. A stronger focus on clinical studies and phytochemical definition of jujube fruits will be essential for future research efforts. This review may be useful for predicting other medicinal uses and potential drug or food interactions and may be beneficial for people living where the jujube fruits are prevalent and health care resources are scarce.

Shergis JL, Ni X, Sarris J, Zhang AL, Guo X, Xue CC, Lu C, Hugel H. Ziziphus spinosa seeds for insomnia: A review of chemistry and psychopharmacology. Phytomedicine. 2017 Oct 15;34:38-43. doi: 10.1016/j.phymed.2017.07.004. Epub 2017 Jul 4. PMID: 28899507.